| Gene Information | |
|---|---|
| Gene Name | ISCU |
| Organism | Homo sapiens (Human) |
| Gene Length | 167 |
| Protein Names | Iron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000136003 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9H1K1 |
| Gene Card | ISCU |
| Uniprot ID | Q9H1K1 |
| Pfam | PF01592 |
| In ASD | no |
| Allosteric Prediction | no (-0.931336892) |
| Ortholog in Animals | Dog_ ISCU ( ortholog_one2one ) GuineaPig_ ISCU ( ortholog_one2one ) Macaque_ ISCU ( ortholog_one2one ) Pig_ ISCU ( ortholog_one2one ) Rat_ Iscu ( ortholog_one2one ) Rabbit_ ISCU ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta. {ECO:0000269|PubMed:11060020, ECO:0000269|PubMed:8875867}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5KZ5 (EM 14.30A ) 5WKP (X-ray 3.15A ) 5WLW (X-ray 3.32A ) 6NZU (EM 3.20A ) 6UXE (X-ray 1.57A ) 6W1D (X-ray 1.79A ) 6WI2 (X-ray 1.95A ) 6WIH (X-ray 1.90A ) 7RTK (X-ray 2.50A ) |
| DBSNP | rs2287555 |
| Subcellular location [CC] | [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:11060020, ECO:0000269|PubMed:26702583}.; [Isoform 2]: Cytoplasm. Nucleus {ECO:0000269|PubMed:11060020}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |