Gene Information
Gene NameCHRM2
OrganismHomo sapiens (Human)
Gene Length466
Protein NamesMuscarinic acetylcholine receptor M2
Target Namemuscarinic acetylcholine receptor m2
Target TypeNA
Gene Age544 ( ENSG00000181072 )
Evolutionary StageEumetazoa
AlphaFoldDBP08172
Gene CardCHRM2
Uniprot IDP08172
PfamPF00001
In ASDyes
Allosteric Predictionyes (1.727748548)
Ortholog in AnimalsAlpaca_ CHRM2 ( ortholog_one2one )
Dog_ CHRM2 ( ortholog_one2one )
GuineaPig_ CHRM2 ( ortholog_one2one )
Macaque_ CHRM2 ( ortholog_one2one )
Mouse_ Chrm2 ( ortholog_one2one )
Pig_ CHRM2 ( ortholog_one2one )
Rat_ Chrm2 ( ortholog_one2one )
Rabbit_ CHRM2 ( ortholog_one2one )
OhnologsCHRM1, CHRM5, CHRM3
ParalogsHRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, GPR161, DRD5, TAAR2
Tissueheart, gall.bladder, left.atrium, left.ventricle, mitral.valve, pulmonary.valve, smooth.muscle, sigmoid.colon
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3UON  (X-ray  3.00A  )  4MQS  (X-ray  3.50A  )  4MQT  (X-ray  3.70A  )  5YC8  (X-ray  2.50A  )  5ZK3  (X-ray  2.60A  )  5ZK8  (X-ray  3.00A  )  5ZKB  (X-ray  2.95A  )  5ZKC  (X-ray  2.30A  )  6OIK  (EM  3.60A  )  6U1N  (EM  4.00A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095};
Multi-pass membrane protein {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733}. Postsynaptic cell membrane {ECO:0000305};
Multi-pass membrane protein {ECO:0000305}. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250|UniProtKB:P06199}.
Mouse PG classificationNA
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