| Gene Information | |
|---|---|
| Gene Name | SIK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 926 |
| Protein Names | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) |
| Target Name | serine/threonine-protein kinase sik2 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000170145 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H0K1 |
| Gene Card | SIK2 |
| Uniprot ID | Q9H0K1 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.370131535) |
| Ortholog in Animals | Alpaca_ SIK2 ( ortholog_one2one ) Dog_ SIK2 ( ortholog_one2one ) GuineaPig_ SIK2 ( ortholog_one2one ) Macaque_ SIK2 ( ortholog_one2one ) Mouse_ Sik2 ( ortholog_one2one ) Pig_ SIK2 ( ortholog_one2one ) Rat_ Sik2 ( ortholog_one2one ) Rabbit_ SIK2 ( ortholog_one2one ) |
| Ohnologs | SIK1 |
| Paralogs | TSSK6, SNRK, SIK3, NIM1K, NUAK2, TSSK2, TSSK4, SIK1, PRKAA2, BRSK2, NUAK1, BRSK1, HUNK, PRKAA1, TSSK1B, MELK, TSSK3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35789057 rs34223841 rs55889697 rs45520245 rs45586732 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24129571}. |
| Mouse PG classification | NA |
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