| Gene Information | |
|---|---|
| Gene Name | IRGM |
| Organism | Homo sapiens (Human) |
| Gene Length | 181 |
| Protein Names | Immunity-related GTPase family M protein (EC 3.6.5.-) (Immunity-related GTPase family M protein 1) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47 homolog) (LRG-47) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 12 ( ENSG00000237693 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | A1A4Y4 |
| Gene Card | IRGM |
| Uniprot ID | A1A4Y4 |
| Pfam | PF05049 |
| In ASD | no |
| Allosteric Prediction | no (-0.249790584) |
| Ortholog in Animals | Alpaca_ IRGM ( ortholog_one2one ) Mouse_ Irgm2 ( ortholog_one2many ) Mouse_ Irgm1 ( ortholog_one2many ) Mouse_ Igtp ( ortholog_one2many ) Rat_ Igtp ( ortholog_one2many ) Rat_ Irgm ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | IRGC |
| Tissue | NA |
| Tissue Specificity | Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes. {ECO:0000269|PubMed:16888103, ECO:0000269|PubMed:17554261}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs180802994 rs72553867 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}. Cell projection, phagocytic cup {ECO:0000250}. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi. {ECO:0000250}. |
| Mouse PG classification | NA |
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