Gene Information
Gene NameIRG1
OrganismHomo sapiens (Human)
Gene Length481
Protein NamesCis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBA6NK06
Gene CardACOD1
Uniprot IDA6NK06
PfamPF03972; PF19305
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6R6U  (X-ray  1.71A 
DBSNP rs767323284  rs1471882722  rs1018207074  rs1289708092  rs755737247 
Subcellular location [CC]Mitochondrion {ECO:0000250|UniProtKB:P54987}.
Mouse PG classificationNA
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