| Gene Information | |
|---|---|
| Gene Name | IRF8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 426 |
| Protein Names | Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000140968 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q02556 |
| Gene Card | IRF8 |
| Uniprot ID | Q02556 |
| Pfam | PF00605; PF10401 |
| In ASD | no |
| Allosteric Prediction | no (-0.059451723) |
| Ortholog in Animals | Alpaca_ IRF8 ( ortholog_one2one ) Dog_ IRF8 ( ortholog_one2one ) Macaque_ IRF8 ( ortholog_one2one ) Mouse_ Irf8 ( ortholog_one2one ) Pig_ IRF8 ( ortholog_one2one ) Rat_ Irf8 ( ortholog_one2one ) Rabbit_ IRF8 ( ortholog_one2one ) |
| Ohnologs | IRF4, IRF9 |
| Paralogs | IRF4, IRF7, IRF5, IRF3, IRF6, IRF9, IRF2, IRF1 |
| Tissue | spleen |
| Tissue Specificity | Predominantly expressed in lymphoid tissues. {ECO:0000269|PubMed:1460054, ECO:0000269|PubMed:23166356}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs397514711 rs397514710 rs1372132995 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:25122610}. Cytoplasm {ECO:0000269|PubMed:25122610}. Note=In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction. {ECO:0000269|PubMed:25122610}. |
| Mouse PG classification | NA |
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