| Gene Information | |
|---|---|
| Gene Name | IRF5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 498 |
| Protein Names | Interferon regulatory factor 5 (IRF-5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000128604 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13568 |
| Gene Card | IRF5 |
| Uniprot ID | Q13568 |
| Pfam | PF00605; PF10401 |
| In ASD | no |
| Allosteric Prediction | no (-0.002204261) |
| Ortholog in Animals | Alpaca_ IRF5 ( ortholog_one2one ) Dog_ IRF5 ( ortholog_one2one ) GuineaPig_ IRF5 ( ortholog_one2one ) Macaque_ IRF5 ( ortholog_one2one ) Mouse_ Irf5 ( ortholog_one2one ) Pig_ IRF5 ( ortholog_one2one ) Rat_ Irf5 ( ortholog_one2one ) Rabbit_ IRF5 ( ortholog_one2one ) |
| Ohnologs | IRF3, IRF6 |
| Paralogs | IRF4, IRF7, IRF3, IRF6, IRF9, IRF2, IRF8, IRF1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3DSH (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}. Nucleus {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}. Note=Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus. {ECO:0000269|PubMed:12138184, ECO:0000269|PubMed:15556946, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418}. |
| Mouse PG classification | NA |
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