| Gene Information | |
|---|---|
| Gene Name | IRF3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | Interferon regulatory factor 3 (IRF-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000126456 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14653 |
| Gene Card | IRF3 |
| Uniprot ID | Q14653 |
| Pfam | PF00605; PF10401 |
| In ASD | no |
| Allosteric Prediction | no (-0.265108732) |
| Ortholog in Animals | Alpaca_ IRF3 ( ortholog_one2one ) Dog_ IRF3 ( ortholog_one2one ) GuineaPig_ IRF3 ( ortholog_one2one ) Macaque_ IRF3 ( ortholog_one2one ) Mouse_ Irf3 ( ortholog_one2one ) Pig_ IRF3 ( ortholog_one2one ) Rat_ Irf3 ( ortholog_one2one ) |
| Ohnologs | IRF5, IRF7 |
| Paralogs | IRF4, IRF7, IRF5, IRF6, IRF9, IRF2, IRF8, IRF1 |
| Tissue | NA |
| Tissue Specificity | Expressed constitutively in a variety of tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002043(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1J2F (X-ray 2.30A ) 1QWT (X-ray 2.10A ) 1T2K (X-ray 3.00A ) 1ZOQ (X-ray 2.37A ) 2O61 (X-ray 2.80A ) 2O6G (X-ray 3.10A ) 2PI0 (X-ray 2.31A ) 3A77 (X-ray 1.80A ) 3QU6 (X-ray 2.30A ) 5JEJ (X-ray 2.00A ) 5JEK (X-ray 2.40A ) 5JEL (X-ray 1.60A ) 5JEM (X-ray 2.50A ) 5JEO (X-ray 1.72A ) 5JER (X-ray 2.91A ) 6SIV (X-ray 1.75A ) 6SJA (X-ray 1.50A ) 7JFL (X-ray 1.68A ) |
| DBSNP | rs968457 rs34745118 rs750526659 rs1049486 rs7251 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:35922005, ECO:0000305|PubMed:25636800}. Nucleus {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:35922005, ECO:0000305|PubMed:25636800}. Mitochondrion {ECO:0000269|PubMed:25609812}. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757, PubMed:35922005). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). {ECO:0000269|PubMed:10805757, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:35922005}. |
| Mouse PG classification | NA |
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