| Gene Information | |
|---|---|
| Gene Name | IRF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 325 |
| Protein Names | Interferon regulatory factor 1 (IRF-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000125347 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P10914 |
| Gene Card | IRF1 |
| Uniprot ID | P10914 |
| Pfam | PF00605 |
| In ASD | no |
| Allosteric Prediction | yes (0.105561494) |
| Ortholog in Animals | Alpaca_ IRF1 ( ortholog_one2one ) Alpaca_ IRF1 ( ortholog_one2many ) Dog_ IRF1 ( ortholog_one2one ) GuineaPig_ IRF1 ( ortholog_one2one ) Macaque_ IRF1 ( ortholog_one2one ) Mouse_ Irf1 ( ortholog_one2one ) Pig_ IRF1 ( ortholog_one2one ) Rat_ Irf1 ( ortholog_one2one ) |
| Ohnologs | IRF2 |
| Paralogs | IRF4, IRF7, IRF5, IRF3, IRF6, IRF9, IRF2, IRF8 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs121912469 rs121912470 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:P15314}. Cytoplasm {ECO:0000250|UniProtKB:P15314}. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1. {ECO:0000250|UniProtKB:P15314}. |
| Mouse PG classification | LPG |
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