Gene Information
Gene NameACSL1
OrganismHomo sapiens (Human)
Gene Length698
Protein NamesLong-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24)
Target Namelong-chain-fatty-acid--coa ligase 1
Target TypeNA
Gene Age>4290 ( ENSG00000151726 )
Evolutionary StageEukaryota
AlphaFoldDBP33121
Gene CardACSL1
Uniprot IDP33121
PfamPF00501; PF13193
In ASDno
Allosteric Predictionyes (0.56298071)
Ortholog in AnimalsAlpaca_ ACSL1 ( ortholog_one2one )
Dog_ ACSL1 ( ortholog_one2one )
GuineaPig_ Acsl1 ( ortholog_one2one )
Macaque_ ACSL1 ( ortholog_one2one )
Mouse_ Acsl1 ( ortholog_one2one )
Pig_ ACSL1 ( ortholog_one2one )
Rat_ Acsl1 ( ortholog_one2one )
OhnologsACSL6, ACSL5
ParalogsSLC27A4, ACSBG1, ACSL3, SLC27A3, ACSL6, ACSBG2, SLC27A6, ACSL4, ACSL5, SLC27A2, SLC27A1, SLC27A5
TissueNA
Tissue SpecificityHighly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. {ECO:0000269|PubMed:10548543}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Mitochondrion outer membrane {ECO:0000250};
Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250};
Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250};
Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24269233};
Single-pass type III membrane protein {ECO:0000250}.
Mouse PG classificationNA
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