| Gene Information | |
|---|---|
| Gene Name | IRS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1338 |
| Protein Names | Insulin receptor substrate 2 (IRS-2) |
| Target Name | insulin receptor substrate 2 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000185950 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y4H2 |
| Gene Card | IRS2 |
| Uniprot ID | Q9Y4H2 |
| Pfam | PF02174; PF00169 |
| In ASD | no |
| Allosteric Prediction | yes (1.202117016) |
| Ortholog in Animals | Alpaca_ IRS2 ( ortholog_one2one ) Dog_ IRS2 ( ortholog_one2one ) Macaque_ IRS2 ( ortholog_one2one ) Mouse_ Irs2 ( ortholog_one2one ) Pig_ IRS2 ( ortholog_one2one ) Rat_ Irs2 ( ortholog_one2one ) |
| Ohnologs | IRS1 |
| Paralogs | IRS4, IRS1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.015867(Mouse);0.001578(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3FQW (X-ray 1.93A ) 3FQX (X-ray 1.70A ) |
| DBSNP | rs35223808 rs549588978 rs201499247 rs35927012 rs1805097 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250}. |
| Mouse PG classification | HPG |
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