Gene Information
Gene NameTGFB2
OrganismHomo sapiens (Human)
Gene Length414
Protein NamesTransforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
Target Nametransforming growth factor beta 2
Target TypeClinical trial target
Gene Age645 ( ENSG00000092969 )
Evolutionary StageEumetazoa
AlphaFoldDBP61812
Gene CardTGFB2
Uniprot IDP61812
PfamPF00019; PF00688
In ASDno
Allosteric Predictionyes (0.39565217)
Ortholog in AnimalsAlpaca_ TGFB2 ( ortholog_one2one )
Dog_ TGFB2 ( ortholog_one2one )
GuineaPig_ TGFB2 ( ortholog_one2one )
Macaque_ TGFB2 ( ortholog_one2one )
Mouse_ Tgfb2 ( ortholog_one2one )
Pig_ TGFB2 ( ortholog_one2one )
Rat_ Tgfb2 ( ortholog_one2one )
Rabbit_ TGFB2 ( ortholog_one2one )
OhnologsTGFB1, TGFB3
ParalogsBMP3, MSTN, INHBC, GDF15, BMP6, INHBA, GDF6, TGFB3, BMP2, BMP10, TGFB1, INHA, GDF9, GDF11, BMP5, BMP7, INHBB, GDF5, GDF1, GDF2, BMP4, LEFTY1, LEFTY2, GDF3, INHBE, GDF7, GDF10, BMP15, BMP8A, BMP8B, NODAL
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1TFG  (X-ray  1.95A  )  2TGI  (X-ray  1.80A  )  4KXZ  (X-ray  2.83A  )  5TX4  (X-ray  1.88A  )  5TY4  (EM  2.90A  )  6I9J  (X-ray  2.00A  )  6XM2  (X-ray  1.91A  )  7RCO  (X-ray  2.90A  ) 
DBSNP rs10482721  rs10482810  rs863223792  rs869312903  rs1553303352  rs387907278 
Subcellular location [CC][Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}.;
[Transforming growth factor beta-2]: Secreted {ECO:0000250|UniProtKB:P01137}.
Mouse PG classificationHPG
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