| Gene Information | |
|---|---|
| Gene Name | MCM4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 863 |
| Protein Names | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000104738 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P33991 |
| Gene Card | MCM4 |
| Uniprot ID | P33991 |
| Pfam | PF00493; PF17855; PF14551; PF17207 |
| In ASD | no |
| Allosteric Prediction | yes (0.683607657) |
| Ortholog in Animals | Alpaca_ MCM4 ( ortholog_one2one ) Dog_ MCM4 ( ortholog_one2one ) GuineaPig_ MCM4 ( ortholog_one2one ) Macaque_ MCM4 ( ortholog_one2one ) Mouse_ Mcm4 ( ortholog_one2one ) Pig_ MCM4 ( ortholog_one2one ) Rat_ Mcm4 ( ortholog_one2many ) Rat_ AC129365.1 ( ortholog_one2many ) Rabbit_ MCM4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MCM9, MCM5, MCM2, MCM6, MCM7, MCM8, MCM3, MCMDC2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.168976(Rat);0.129005(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6XTX (EM 3.29A ) 6XTY (EM 6.77A ) 7PFO (EM 3.20A ) 7PLO (EM 2.80A ) |
| DBSNP | rs17287663 rs762679 |
| Subcellular location [CC] | Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000305|PubMed:35585232}. |
| Mouse PG classification | NA |
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