| Gene Information | |
|---|---|
| Gene Name | IQSEC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1182 |
| Protein Names | IQ motif and SEC7 domain-containing protein 3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000120645 ) 3 ( ENSG00000262607 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9UPP2 |
| Gene Card | IQSEC3 |
| Uniprot ID | Q9UPP2 |
| Pfam | PF16453; PF01369 |
| In ASD | no |
| Allosteric Prediction | no (-0.83219612) |
| Ortholog in Animals | Alpaca_ IQSEC3 ( ortholog_one2one ) GuineaPig_ IQSEC3 ( ortholog_one2one ) Macaque_ IQSEC3 ( ortholog_one2one ) Mouse_ Iqsec3 ( ortholog_one2one ) Pig_ IQSEC3 ( ortholog_one2one ) Rat_ Iqsec3 ( ortholog_one2one ) Rabbit_ IQSEC3 ( ortholog_one2one ) |
| Ohnologs | IQSEC1 |
| Paralogs | PSD2, PSD3, ARFGEF2, CYTH4, MON2, GBF1, ARFGEF1, PSD, PSD4, FBXO8, CYTH1, IQSEC1, CYTH2, IQSEC2, CYTH3 |
| Tissue | adipose.tissue, brain, cerebellum, occipital.lobe, cerebellar.hemisphere, cerebral.cortex |
| Tissue Specificity | Expressed specifically in the adult brain, predominantly in the cerebral cortex and the olfactory bulb, but not in the fetal brain. Expressed only in mature neurons, but not in undifferentiated neural stem precursor cells (NSPCs), nor in glioma cells. {ECO:0000269|PubMed:17981261}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs56204927 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17981261}. Postsynaptic density {ECO:0000250|UniProtKB:Q3TES0}. |
| Mouse PG classification | NA |
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