Gene Information
Gene NameIQSEC1
OrganismHomo sapiens (Human)
Gene Length963
Protein NamesIQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2)
Target NameNA
Target TypeNA
Gene Age>4290 ( ENSG00000144711 )
Evolutionary StageEumetazoa
AlphaFoldDBQ6DN90
Gene CardIQSEC1
Uniprot IDQ6DN90
PfamPF16453; PF01369
In ASDyes
Allosteric Predictionyes (0.358672096)
Ortholog in AnimalsAlpaca_ IQSEC1 ( ortholog_one2one )
GuineaPig_ IQSEC1 ( ortholog_one2one )
Macaque_ IQSEC1 ( ortholog_one2one )
Mouse_ Iqsec1 ( ortholog_one2one )
Pig_ IQSEC1 ( ortholog_one2one )
Rat_ Iqsec1 ( ortholog_one2one )
Rabbit_ IQSEC1 ( ortholog_one2one )
OhnologsIQSEC3, IQSEC2
ParalogsPSD2, PSD3, ARFGEF2, CYTH4, MON2, GBF1, ARFGEF1, PSD, PSD4, FBXO8, CYTH1, IQSEC3, CYTH2, IQSEC2, CYTH3
TissueNA
Tissue SpecificityExpressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. {ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:9872452}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3QWM  (X-ray  2.39A  )  4C0A  (X-ray  3.30A  )  5NLV  (X-ray  2.40A  )  5NLY  (X-ray  2.00A  )  6FNE  (X-ray  2.50A  ) 
DBSNP rs758170522  rs765723607  rs35319679  rs17541405 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:11226253}. Nucleus {ECO:0000269|PubMed:11226253}. Postsynaptic density {ECO:0000250|UniProtKB:Q8R0S2}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q8R0S2}. Note=At steady state, may be preferentially cytosolic.
Mouse PG classificationNA
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