| Gene Information | |
|---|---|
| Gene Name | MPP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 576 |
| Protein Names | MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000108852 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14168 |
| Gene Card | MPP2 |
| Uniprot ID | Q14168 |
| Pfam | PF00625; PF02828; PF00595; PF07653 |
| In ASD | no |
| Allosteric Prediction | no (-0.22624421) |
| Ortholog in Animals | Alpaca_ MPP2 ( ortholog_one2one ) Dog_ MPP2 ( ortholog_one2one ) GuineaPig_ MPP2 ( ortholog_one2one ) Macaque_ MPP2 ( ortholog_one2one ) Mouse_ Mpp2 ( ortholog_one2one ) Pig_ MPP2 ( ortholog_one2one ) Rat_ Mpp2 ( ortholog_one2one ) Rabbit_ MPP2 ( ortholog_one2one ) |
| Ohnologs | PALS2 |
| Paralogs | MPP3, MPP7, PALS1, CASK, PALS2, MPP1, MPP4 |
| Tissue | cerebral.cortex, testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2E7K (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19665017}. Membrane {ECO:0000269|PubMed:19665017}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9WV34}. Postsynaptic density {ECO:0000250|UniProtKB:Q9WV34}. Note=Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts. {ECO:0000250|UniProtKB:Q9WV34}. |
| Mouse PG classification | NA |
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