| Gene Information | |
|---|---|
| Gene Name | INVS |
| Organism | Homo sapiens (Human) |
| Gene Length | 1065 |
| Protein Names | Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000119509 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y283 |
| Gene Card | INVS |
| Uniprot ID | Q9Y283 |
| Pfam | PF00023; PF12796; PF00612 |
| In ASD | no |
| Allosteric Prediction | no (-1.194181736) |
| Ortholog in Animals | Alpaca_ INVS ( ortholog_one2one ) Dog_ INVS ( ortholog_one2one ) GuineaPig_ INVS ( ortholog_one2one ) Macaque_ INVS ( ortholog_one2one ) Mouse_ Invs ( ortholog_one2one ) Pig_ INVS ( ortholog_one2one ) Rat_ Invs ( ortholog_one2one ) Rabbit_ INVS ( ortholog_one2one ) |
| Ohnologs | ANKRD44 |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Strongly expressed in the primary cilia of renal tubular cells. {ECO:0000269|PubMed:11935322, ECO:0000269|PubMed:12872123}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2491097 rs121964995 rs1052867 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, cilium {ECO:0000269|PubMed:12872123}. Note=Associates with several components of the cytoskeleton including ciliary, random and polarized microtubules. During mitosis, it is recruited to mitotic spindle. Frequently membrane-associated, membrane localization is dependent upon cell-cell contacts and is redistributed when cell adhesion is disrupted after incubation of the cell monolayer with low-calcium/EGTA medium. |
| Mouse PG classification | HPG |
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