| Gene Information | |
|---|---|
| Gene Name | ANK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 3957 |
| Protein Names | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000145362 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | ANK2 |
| Uniprot ID | Q01484 |
| Pfam | PF00023; PF12796; PF13637; PF00531; PF17809; PF00791 |
| In ASD | no |
| Allosteric Prediction | yes (0.472025461) |
| Ortholog in Animals | Alpaca_ ANK2 ( ortholog_one2one ) Dog_ ANK2 ( ortholog_one2one ) GuineaPig_ ANK2 ( ortholog_one2one ) Macaque_ ANK2 ( ortholog_one2one ) Mouse_ Ank2 ( ortholog_one2one ) Rat_ Ank2 ( ortholog_one2one ) Rabbit_ ANK2 ( ortholog_one2one ) |
| Ohnologs | ANK1, ANK3 |
| Paralogs | ANK1, ASB7, ANK3 |
| Tissue | NA |
| Tissue Specificity | Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain and in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina. {ECO:0000269|PubMed:1830053, ECO:0000269|PubMed:1833308, ECO:0000269|PubMed:19007774}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4D8O (X-ray 2.20A ) 4RLV (X-ray 3.49A ) 4RLY (X-ray 2.50A ) 5Y4D (X-ray 3.30A ) 5Y4E (X-ray 2.34A ) 5Y4F (X-ray 1.95A ) 5YIR (X-ray 2.75A ) 5YIS (X-ray 2.20A ) 6KZJ (X-ray 1.50A ) 6M3Q (X-ray 3.44A ) |
| DBSNP | rs29372 rs72544141 rs28377576 rs35530544 rs121912705 rs121912706 rs45454496 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19007774}. Membrane {ECO:0000269|PubMed:19007774}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q8C8R3}. Apical cell membrane {ECO:0000250|UniProtKB:Q8C8R3}. Cell membrane {ECO:0000269|PubMed:19007774}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q8C8R3}. Early endosome {ECO:0000250|UniProtKB:Q8C8R3}. Recycling endosome {ECO:0000250|UniProtKB:Q8C8R3}. Lysosome {ECO:0000250|UniProtKB:Q8C8R3}. Mitochondrion {ECO:0000250|UniProtKB:Q8C8R3}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q8C8R3}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q8C8R3}. Note=Expressed at the apical membrane of airway lung epithelial cells (By similarity). Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distinct intracellular compartment of neonatal cardiomyocytes (PubMed:19007774). In skeletal muscle, localizes to neuromuscular junctions (By similarity). Localizes with puncta at mitochondria ends. Colocalizes and cotransports on motile vesicles with RABGAP1L (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:19007774}. |
| Mouse PG classification | NA |
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