| Gene Information | |
|---|---|
| Gene Name | INTS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1043 |
| Protein Names | Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000143624 ) 3 ( ENSG00000262826 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q68E01 |
| Gene Card | INTS3 |
| Uniprot ID | Q68E01 |
| Pfam | PF10189 |
| In ASD | no |
| Allosteric Prediction | no (-0.556584801) |
| Ortholog in Animals | Alpaca_ INTS3 ( ortholog_one2one ) Dog_ INTS3 ( ortholog_one2one ) GuineaPig_ INTS3 ( ortholog_one2one ) Macaque_ INTS3 ( ortholog_one2one ) Mouse_ Ints3 ( ortholog_one2one ) Pig_ INTS3 ( ortholog_one2one ) Rat_ Ints3 ( ortholog_one2one ) Rabbit_ INTS3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001578(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4OWT (X-ray 2.00A ) 4OWW (X-ray 2.30A ) 4OWX (X-ray 2.30A ) 6WLG (X-ray 3.11A ) 7BV7 (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501, ECO:0000269|PubMed:23904267}. Cytoplasm {ECO:0000269|PubMed:23904267}. Note=Localizes to nuclear foci following DNA damage. |
| Mouse PG classification | NA |
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