Gene Information
Gene NameDGKB
OrganismHomo sapiens (Human)
Gene Length804
Protein NamesDiacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta)
Target Namediacylglycerol kinase
Target TypeNA
Gene Age987 ( ENSG00000136267 )
Evolutionary StageEukaryota
AlphaFoldDBQ9Y6T7
Gene CardDGKB
Uniprot IDQ9Y6T7
PfamPF00130; PF14513; PF00609; PF00781; PF13499
In ASDno
Allosteric Predictionyes (0.236525388)
Ortholog in AnimalsAlpaca_ DGKB ( ortholog_one2one )
Dog_ DGKB ( ortholog_one2one )
Macaque_ DGKB ( ortholog_one2one )
Mouse_ Dgkb ( ortholog_one2one )
Pig_ DGKB ( ortholog_one2one )
Rat_ Dgkb ( ortholog_one2one )
Rabbit_ DGKB ( ortholog_one2one )
OhnologsDGKA, DGKG
ParalogsDGKQ, DGKE, DGKG, DGKH, DGKI, DGKD, DGKA, DGKK, DGKZ
Tissuebrain, cerebral.cortex
Tissue Specificity[Isoform 1]: Specifically expressed in brain but also detected in uterus (PubMed:11719522). In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus (PubMed:11719522). {ECO:0000269|PubMed:11719522}.;
[Isoform 2]: More ubiquitously expressed but at lower level compared to isoform 1. {ECO:0000269|PubMed:11719522}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs34616903 
Subcellular location [CC]Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q6NS52};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NS52}. Cell membrane {ECO:0000269|PubMed:11719522};
Peripheral membrane protein {ECO:0000305|PubMed:11719522}. Cytoplasm {ECO:0000269|PubMed:11719522}. Note=Translocation to the plasma membrane is induced by phorbol esters. {ECO:0000269|PubMed:11719522}.;
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11719522}.
Mouse PG classificationNA
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