Gene Information
Gene NameHK1
OrganismHomo sapiens (Human)
Gene Length917
Protein NamesHexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A)
Target Namehexokinase-1
Target TypeNA
Gene Age1292 ( ENSG00000156515 )
Evolutionary StageEuk+Bac
AlphaFoldDBP19367
Gene CardHK1
Uniprot IDP19367
PfamPF00349; PF03727
In ASDyes
Allosteric Predictionyes (1.434383352)
Ortholog in AnimalsAlpaca_ HK1 ( ortholog_one2one )
Dog_ HK1 ( ortholog_one2one )
GuineaPig_ HK1 ( ortholog_one2one )
Macaque_ HK1 ( ortholog_one2one )
Mouse_ Hk1 ( ortholog_one2one )
Pig_ HK1 ( ortholog_one2one )
Rat_ Hk1 ( ortholog_one2one )
Rabbit_ HK1 ( ortholog_one2one )
OhnologsGCK, HK2, HK3
ParalogsHKDC1, HK2, HK3, GCK
Tissuetestis
Tissue SpecificityIsoform 2: Erythrocyte specific (Ref.6). Isoform 3: Testis-specific (PubMed:10978502). Isoform 4: Testis-specific (PubMed:10978502). {ECO:0000269|PubMed:10978502, ECO:0000269|Ref.6}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CZA  (X-ray  1.90A  )  1DGK  (X-ray  2.80A  )  1HKB  (X-ray  2.80A  )  1HKC  (X-ray  2.80A  )  1QHA  (X-ray  2.25A  )  4F9O  (X-ray  2.65A  )  4FOE  (X-ray  2.70A  )  4FOI  (X-ray  2.40A  )  4FPA  (X-ray  2.48A  )  4FPB  (X-ray  3.00A  ) 
DBSNP rs1064795154  rs1564557037  rs1064794848  rs1057517928  rs137853249  rs398122379  rs1054203  rs777849213 
Subcellular location [CC]Mitochondrion outer membrane {ECO:0000269|PubMed:1985912, ECO:0000269|PubMed:27374331};
Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:27374331}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (Probable). Dissociates from the mitochondrial outer membrane following inhibition by N-acetyl-D-glucosamine, leading to relocation to the cytosol (PubMed:27374331). {ECO:0000269|PubMed:27374331, ECO:0000305|PubMed:1985912}.
Mouse PG classificationNA
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