| Gene Information | |
|---|---|
| Gene Name | FCMR |
| Organism | Homo sapiens (Human) |
| Gene Length | 390 |
| Protein Names | Fas apoptotic inhibitory molecule 3 (IgM Fc fragment receptor) (Regulator of Fas-induced apoptosis Toso) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000162894 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O60667 |
| Gene Card | FCMR |
| Uniprot ID | O60667 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-1.201166767) |
| Ortholog in Animals | Alpaca_ FCMR ( ortholog_one2one ) Dog_ FCMR ( ortholog_one2one ) GuineaPig_ FCMR ( ortholog_one2one ) Macaque_ FCMR ( ortholog_one2one ) Mouse_ Fcmr ( ortholog_one2one ) Pig_ FCMR ( ortholog_one2one ) Rat_ Fcmr ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TREML1, FCAMR, CD300LD, TMIGD3, CD300H, CD300LF, CD300C, CD300LG, CD300A, PIGR, CD300E, TREM2, CD300LB |
| Tissue | spleen |
| Tissue Specificity | Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells. {ECO:0000269|PubMed:21908424, ECO:0000269|PubMed:9586636}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Membrane {ECO:0000269|PubMed:21908424}; Single-pass membrane protein {ECO:0000255}.; [Isoform 3]: Secreted {ECO:0000269|PubMed:21908424}. Note=Detected in the serum. {ECO:0000269|PubMed:21908424}. |
| Mouse PG classification | NA |
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