| Gene Information | |
|---|---|
| Gene Name | INSRR |
| Organism | Homo sapiens (Human) |
| Gene Length | 1297 |
| Protein Names | Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] |
| Target Name | insulin receptor-related protein |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000027644 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P14616 |
| Gene Card | INSRR |
| Uniprot ID | P14616 |
| Pfam | PF00757; PF07714; PF01030 |
| In ASD | no |
| Allosteric Prediction | yes (0.071341775) |
| Ortholog in Animals | Alpaca_ INSRR ( ortholog_one2one ) Dog_ INSRR ( ortholog_one2one ) GuineaPig_ INSRR ( ortholog_one2one ) Macaque_ INSRR ( ortholog_one2one ) Mouse_ Insrr ( ortholog_one2one ) Pig_ INSRR ( ortholog_one2one ) Rat_ Insrr ( ortholog_one2one ) Rabbit_ INSRR ( ortholog_one2one ) |
| Ohnologs | IGF1R, INSR |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.008696(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7PL4 (NMR - ) |
| DBSNP | rs55757706 rs55971900 rs55951840 rs56377825 rs56068937 rs56252149 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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