Gene Information
Gene NameIL2RB
OrganismHomo sapiens (Human)
Gene Length551
Protein NamesInterleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Target Nameinterleukin-2 receptor subunit beta
Target TypeNA
Gene Age544 ( ENSG00000100385 )
Evolutionary StageVertebrata
AlphaFoldDBP14784
Gene CardIL2RB
Uniprot IDP14784
PfamPF18707
In ASDno
Allosteric Predictionno (-0.118262671)
Ortholog in AnimalsAlpaca_ IL2RB ( ortholog_one2one )
Dog_ IL2RB ( ortholog_one2one )
GuineaPig_ IL2RB ( ortholog_one2one )
Macaque_ IL2RB ( ortholog_one2one )
Mouse_ Il2rb ( ortholog_one2one )
Pig_ IL2RB ( ortholog_one2one )
Rat_ Il2rb ( ortholog_one2one )
OhnologsNA
ParalogsMPL, IL4R, IL7R, IL9R, IL21R, CSF2RB, EPOR
Tissueplacenta, spleen, whole.blood
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2B5I  (X-ray  2.30A  2ERJ  (X-ray  3.00A  3QAZ  (X-ray  3.80A  4GS7  (X-ray  2.35A  5M5E  (X-ray  2.30A  6E8K  (X-ray  1.71A  7S2S  (X-ray  1.93A 
DBSNP rs57770674  rs934523851  rs2228143  rs228942 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:31040184, ECO:0000269|PubMed:31040185};
Single-pass type I membrane protein {ECO:0000255}.
Mouse PG classificationNA
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