Gene Information
Gene NameIMPDH2
OrganismHomo sapiens (Human)
Gene Length514
Protein NamesInosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II)
Target Nameinosine-5'-monophosphate dehydrogenase 2
Target TypeSuccessful target
Gene Age886 ( ENSG00000178035 )
Evolutionary StageCellular_organisms
AlphaFoldDBP12268
Gene CardIMPDH2
Uniprot IDP12268
PfamPF00571; PF00478
In ASDyes
Allosteric Predictionyes (1.000130476)
Ortholog in AnimalsAlpaca_ IMPDH2 ( ortholog_one2one )
Dog_ IMPDH2 ( ortholog_one2one )
GuineaPig_ IMPDH2 ( ortholog_one2one )
Macaque_ IMPDH2 ( ortholog_one2one )
Mouse_ Impdh2 ( ortholog_one2one )
Pig_ IMPDH2 ( ortholog_one2one )
Rat_ Impdh2 ( ortholog_one2one )
Rabbit_ IMPDH2 ( ortholog_one2one )
OhnologsIMPDH1
ParalogsIMPDH1, GMPR2, GMPR
TissueNA
Tissue SpecificityIMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1B3O  (X-ray  2.90A  )  1NF7  (X-ray  2.65A  )  1NFB  (X-ray  2.90A  )  6I0M  (X-ray  2.57A  )  6I0O  (X-ray  2.62A  )  6U8E  (EM  3.03A  )  6U8N  (EM  3.29A  )  6U8R  (EM  3.91A  )  6U8S  (EM  3.14A  )  6U9O  (EM  3.36A  )  6UA2  (EM  4.20A  )  6UA4  (EM  3.65A  )  6UA5  (EM  3.79A  )  6UAJ  (EM  3.84A  )  6UC2  (EM  4.48A  )  6UDO  (EM  3.21A  )  6UDP  (EM  2.95A  )  6UDQ  (EM  3.27A  ) 
DBSNP rs121434586 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000269|PubMed:14766016}. Cytoplasm, cytosol {ECO:0000269|PubMed:31337707}. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion. {ECO:0000269|PubMed:24477477, ECO:0000269|PubMed:31337707}.
Mouse PG classificationNA
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