| Gene Information | |
|---|---|
| Gene Name | INSC |
| Organism | Homo sapiens (Human) |
| Gene Length | 579 |
| Protein Names | Protein inscuteable homolog |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000188487 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q1MX18 |
| Gene Card | INSC |
| Uniprot ID | Q1MX18 |
| Pfam | PF19427; PF16748 |
| In ASD | no |
| Allosteric Prediction | no (-0.983952335) |
| Ortholog in Animals | Alpaca_ INSC ( ortholog_one2one ) Dog_ INSC ( ortholog_one2one ) GuineaPig_ INSC ( ortholog_one2one ) Macaque_ INSC ( ortholog_one2one ) Mouse_ Insc ( ortholog_one2one ) Pig_ INSC ( ortholog_one2one ) Rat_ Insc ( ortholog_one2one ) Rabbit_ INSC ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | bone.marrow |
| Tissue Specificity | Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas. {ECO:0000269|PubMed:12469229, ECO:0000269|PubMed:16458856}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3SF4 (X-ray 2.60A ) |
| DBSNP | rs17507577 rs7123855 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:22074847}. Cytoplasm, cell cortex {ECO:0000269|PubMed:22074847}. Note=Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles. {ECO:0000269|PubMed:22074847}. |
| Mouse PG classification | NA |
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