Home
Genetic Feature
Search By Gene Name
Search By Disease Name
Evolutionary Feature
Search By Gene Name
Search By Ohnolog
Search By Ortholog
Allosteric Protein
Drug
Browse
Browse By Gene Name
Browse By Drug Name
Browse By Disease Name
Browse By Evolutionary Stage
Help
Download
Gene Information
Gene Name
INS
Organism
Homo sapiens (Human)
Gene Length
110
Protein Names
Insulin [Cleaved into: Insulin B chain; Insulin A chain]
Target Name
insulin
Target Type
NA
Gene Age
3 ( ENSG00000254647 )
Evolutionary Stage
Vertebrata
AlphaFoldDB
P01308
Gene Card
INS
Uniprot ID
P01308
Pfam
PF00049
In ASD
yes
Allosteric Prediction
yes (0.999888157)
Ortholog in Animals
Alpaca_ INS ( ortholog_one2one )
Dog_ INS ( ortholog_one2one )
GuineaPig_ INS ( ortholog_one2one )
Macaque_ INS ( ortholog_one2one )
Mouse_ Ins1 ( ortholog_one2many )
Mouse_ Ins2 ( ortholog_one2many )
Pig_ INS ( ortholog_one2one )
Rat_ Ins1 ( ortholog_one2many )
Rat_ Ins2 ( ortholog_one2many )
Rabbit_ INS ( ortholog_one2one )
Ohnologs
NA
Paralogs
IGF1, IGF2
Tissue
pancreas
Tissue Specificity
NA
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.001578(Rat);0.019048(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1A7F
(NMR
-
)
1AI0
(NMR
-
)
1AIY
(NMR
-
)
1B9E
(X-ray
2.50A
)
1BEN
(X-ray
1.40A
)
1EFE
(NMR
-
)
1EV3
(X-ray
1.78A
)
1EV6
(X-ray
1.90A
)
1EVR
(X-ray
1.90A
)
1FU2
(X-ray
3.24A
)
1FUB
(X-ray
3.09A
)
1G7A
(X-ray
1.20A
)
1G7B
(X-ray
1.30A
)
1GUJ
(X-ray
1.62A
)
1HIQ
(NMR
-
)
1HIS
(NMR
-
)
1HIT
(NMR
-
)
1HLS
(NMR
-
)
1HTV
(X-ray
1.90A
)
1HUI
(NMR
-
)
1IOG
(NMR
-
)
1IOH
(NMR
-
)
1J73
(X-ray
2.00A
)
1JCA
(X-ray
2.50A
)
1JCO
(NMR
-
)
1JK8
(X-ray
2.40A
)
1K3M
(NMR
-
)
1KMF
(NMR
-
)
1LKQ
(NMR
-
)
1LPH
(X-ray
2.30A
)
1MHI
(NMR
-
)
1MHJ
(NMR
-
)
1MSO
(X-ray
1.00A
)
1OS3
(X-ray
1.95A
)
1OS4
(X-ray
2.25A
)
1Q4V
(X-ray
2.00A
)
1QIY
(X-ray
2.30A
)
1QIZ
(X-ray
2.00A
)
1QJ0
(X-ray
2.40A
)
1RWE
(X-ray
1.80A
)
1SF1
(NMR
-
)
1SJT
(NMR
-
)
1SJU
(NMR
-
)
1T0C
(NMR
-
)
1T1K
(NMR
-
)
1T1P
(NMR
-
)
1T1Q
(NMR
-
)
1TRZ
(X-ray
1.60A
)
1TYL
(X-ray
1.90A
)
1TYM
(X-ray
1.90A
)
1UZ9
(X-ray
1.60A
)
1VKT
(NMR
-
)
1W8P
(X-ray
2.08A
)
1XDA
(X-ray
1.80A
)
1XGL
(NMR
-
)
1XW7
(X-ray
2.30A
)
1ZEG
(X-ray
1.60A
)
1ZEH
(X-ray
1.50A
)
1ZNJ
(X-ray
2.00A
)
2AIY
(NMR
-
)
2C8Q
(X-ray
1.95A
)
2C8R
(X-ray
1.50A
)
2CEU
(X-ray
1.80A
)
2G54
(X-ray
2.25A
)
2G56
(X-ray
2.20A
)
2H67
(NMR
-
)
2HH4
(NMR
-
)
2HHO
(NMR
-
)
2HIU
(NMR
-
)
2JMN
(NMR
-
)
2JUM
(NMR
-
)
2JUU
(NMR
-
)
2JUV
(NMR
-
)
2JV1
(NMR
-
)
2JZQ
(NMR
-
)
2K91
(NMR
-
)
2K9R
(NMR
-
)
2KJJ
(NMR
-
)
2KJU
(NMR
-
)
2KQP
(NMR
-
)
2KQQ
(NMR
-
)
2KXK
(NMR
-
)
2L1Y
(NMR
-
)
2L1Z
(NMR
-
)
2LGB
(NMR
-
)
2LWZ
(NMR
-
)
2M1D
(NMR
-
)
2M1E
(NMR
-
)
2M2M
(NMR
-
)
2M2N
(NMR
-
)
2M2O
(NMR
-
)
2M2P
(NMR
-
)
2MLI
(NMR
-
)
2MPG
(NMR
-
)
2MPI
(NMR
-
)
2MVC
(NMR
-
)
2MVD
(NMR
-
)
2N2V
(NMR
-
)
2N2W
(NMR
-
)
2N2X
(NMR
-
)
2OLY
(X-ray
1.70A
)
2OLZ
(X-ray
1.70A
)
2OM0
(X-ray
2.05A
)
2OM1
(X-ray
1.97A
)
2OMG
(X-ray
1.52A
)
2OMH
(X-ray
1.36A
)
2OMI
(X-ray
2.24A
)
2OMQ
(X-ray
2.00A
)
2QIU
(X-ray
2.00A
)
2R34
(X-ray
2.25A
)
2R35
(X-ray
2.08A
)
2R36
(X-ray
2.00A
)
2RN5
(NMR
-
)
2VJZ
(X-ray
1.80A
)
2VK0
(X-ray
2.20A
)
2W44
(X-ray
2.00A
)
2WBY
(X-ray
2.60A
)
2WC0
(X-ray
2.80A
)
2WRU
(X-ray
1.57A
)
2WRV
(X-ray
2.15A
)
2WRW
(X-ray
2.41A
)
2WRX
(X-ray
1.50A
)
2WS0
(X-ray
2.10A
)
2WS1
(X-ray
1.60A
)
2WS4
(X-ray
1.90A
)
2WS6
(X-ray
1.50A
)
2WS7
(X-ray
2.59A
)
3AIY
(NMR
-
)
3BXQ
(X-ray
1.30A
)
3E7Y
(X-ray
1.60A
)
3E7Z
(X-ray
1.70A
)
3EXX
(X-ray
1.35A
)
3FQ9
(X-ray
1.35A
)
3HYD
(X-ray
1.00A
)
3I3Z
(X-ray
1.60A
)
3I40
(X-ray
1.85A
)
3ILG
(X-ray
1.90A
)
3INC
(X-ray
1.85A
)
3IR0
(X-ray
2.20A
)
3JSD
(X-ray
2.50A
)
3KQ6
(X-ray
1.90A
)
3P2X
(X-ray
2.00A
)
3P33
(X-ray
2.30A
)
3Q6E
(X-ray
2.05A
)
3ROV
(X-ray
2.30A
)
3TT8
(X-ray
1.12A
)
3U4N
(X-ray
1.98A
)
3UTQ
(X-ray
1.67A
)
3UTS
(X-ray
2.71A
)
3UTT
(X-ray
2.60A
)
3V19
(X-ray
2.00A
)
3V1G
(X-ray
2.20A
)
3W11
(X-ray
3.90A
)
3W12
(X-ray
4.30A
)
3W13
(X-ray
4.30A
)
3W7Y
(X-ray
0.92A
)
3W7Z
(X-ray
1.15A
)
3W80
(X-ray
1.40A
)
3ZI3
(X-ray
1.70A
)
3ZQR
(X-ray
1.90A
)
3ZS2
(X-ray
1.97A
)
3ZU1
(X-ray
1.60A
)
4AIY
(NMR
-
)
4AJX
(X-ray
1.20A
)
4AJZ
(X-ray
1.80A
)
4AK0
(X-ray
2.28A
)
4AKJ
(X-ray
2.01A
)
4CXL
(X-ray
1.50A
)
4CXN
(X-ray
1.70A
)
4CY7
(X-ray
1.40A
)
4EFX
(X-ray
1.98A
)
4EWW
(X-ray
2.30A
)
4EWX
(X-ray
2.20A
)
4EWZ
(X-ray
1.79A
)
4EX0
(X-ray
1.86A
)
4EX1
(X-ray
1.66A
)
4EXX
(X-ray
1.55A
)
4EY1
(X-ray
1.47A
)
4EY9
(X-ray
1.47A
)
4EYD
(X-ray
1.47A
)
4EYN
(X-ray
1.53A
)
4EYP
(X-ray
1.59A
)
4F0N
(X-ray
1.68A
)
4F0O
(X-ray
1.67A
)
4F1A
(X-ray
1.80A
)
4F1B
(X-ray
1.59A
)
4F1C
(X-ray
1.70A
)
4F1D
(X-ray
1.64A
)
4F1F
(X-ray
1.68A
)
4F1G
(X-ray
1.64A
)
4F4T
(X-ray
1.64A
)
4F4V
(X-ray
1.64A
)
4F51
(X-ray
1.64A
)
4F8F
(X-ray
1.68A
)
4FG3
(X-ray
2.00A
)
4FKA
(X-ray
1.08A
)
4GBC
(X-ray
1.78A
)
4GBI
(X-ray
2.50A
)
4GBK
(X-ray
2.40A
)
4GBL
(X-ray
2.50A
)
4GBN
(X-ray
1.87A
)
4IUZ
(X-ray
1.60A
)
4IYD
(X-ray
1.66A
)
4IYF
(X-ray
1.80A
)
4NIB
(X-ray
1.40A
)
4OGA
(X-ray
3.50A
)
4P65
(X-ray
1.50A
)
4RXW
(X-ray
1.73A
)
4UNE
(X-ray
1.59A
)
4UNG
(X-ray
1.81A
)
4UNH
(X-ray
2.75A
)
4WDI
(X-ray
2.31A
)
4XC4
(X-ray
1.50A
)
4Y19
(X-ray
2.50A
)
4Y1A
(X-ray
4.00A
)
4Z76
(X-ray
1.88A
)
4Z77
(X-ray
1.85A
)
4Z78
(X-ray
2.30A
)
5AIY
(NMR
-
)
5BOQ
(X-ray
1.70A
)
5BPO
(X-ray
1.90A
)
5BQQ
(X-ray
1.54A
)
5BTS
(X-ray
1.77A
)
5C0D
(X-ray
1.68A
)
5CJO
(X-ray
3.29A
)
5CNY
(X-ray
1.70A
)
5CO2
(X-ray
1.70A
)
5CO6
(X-ray
1.80A
)
5CO9
(X-ray
1.92A
)
5E7W
(X-ray
0.95A
)
5EMS
(X-ray
2.30A
)
5EN9
(X-ray
1.50A
)
5ENA
(X-ray
1.35A
)
5HPR
(X-ray
1.33A
)
5HPU
(X-ray
2.20A
)
5HQI
(X-ray
0.97A
)
5HRQ
(X-ray
1.28A
)
5HYJ
(X-ray
3.06A
)
5MAM
(X-ray
2.20A
)
5MHD
(NMR
-
)
5MT3
(X-ray
2.02A
)
5MT9
(X-ray
1.88A
)
5MWQ
(NMR
-
)
5T7R
(X-ray
1.55A
)
5UDP
(X-ray
1.35A
)
5UOZ
(X-ray
1.17A
)
5UQA
(X-ray
1.31A
)
5URT
(X-ray
1.18A
)
5URU
(X-ray
2.41A
)
5USP
(X-ray
1.17A
)
5USS
(X-ray
2.06A
)
5USV
(X-ray
1.30A
)
5UU2
(X-ray
1.22A
)
5UU3
(X-ray
2.25A
)
5UU4
(X-ray
1.97A
)
5VIZ
(X-ray
1.70A
)
5WBT
(NMR
-
)
5WDM
(X-ray
2.80A
)
5WOB
(X-ray
3.95A
)
6B3Q
(EM
3.70A
)
6B70
(EM
3.70A
)
6BFC
(EM
3.70A
)
6CE7
(EM
7.40A
)
6CE9
(EM
4.30A
)
6CEB
(EM
4.70A
)
6CK2
(X-ray
2.25A
)
6GNQ
(X-ray
2.20A
)
6GV0
(X-ray
1.26A
)
6H3M
(X-ray
1.82A
)
6HN5
(EM
3.20A
)
6JK8
(EM
4.70A
)
6JR3
(EM
14.50A
)
6K59
(NMR
-
)
6NWV
(X-ray
1.60A
)
6O17
(X-ray
1.58A
)
6P4Z
(X-ray
1.80A
)
6S34
(X-ray
1.35A
)
6S4I
(X-ray
1.51A
)
6S4J
(X-ray
1.50A
)
6SOF
(EM
4.30A
)
6TC2
(X-ray
1.36A
)
6TYH
(X-ray
1.60A
)
6U46
(NMR
-
)
6VEP
(X-ray
2.90A
)
6VER
(X-ray
1.05A
)
6VES
(X-ray
1.85A
)
6VET
(X-ray
1.46A
)
6X4X
(NMR
-
)
6Z7W
(X-ray
2.42A
)
6Z7Y
(X-ray
2.20A
)
7BW7
(EM
4.10A
)
7BW8
(EM
3.80A
)
7BWA
(EM
4.90A
)
7JP3
(X-ray
1.95A
)
7KD6
(X-ray
2.60A
)
7MD4
(EM
4.50A
)
7MD5
(EM
5.20A
)
7MQO
(EM
3.40A
)
7MQR
(EM
4.10A
)
7MQS
(EM
4.40A
)
7NHU
(X-ray
1.40A
)
7PG0
(EM
7.60A
)
7PG2
(EM
6.70A
)
7PG3
(EM
7.30A
)
7PG4
(EM
9.10A
)
7QGF
(X-ray
1.20A
)
7QID
(EM
5.00A
)
7RKD
(X-ray
1.25A
)
7RZE
(EM
3.30A
)
7RZF
(EM
3.40A
)
7RZI
(EM
3.00A
)
7S4Y
(X-ray
1.71A
)
7SL1
(EM
3.40A
)
7SL2
(EM
3.60A
)
7SL3
(EM
3.40A
)
7SL4
(EM
5.00A
)
7SL6
(EM
3.70A
)
7SL7
(EM
3.10A
)
7STH
(EM
3.50A
)
7STI
(EM
4.90A
)
7STJ
(EM
4.40A
)
7STK
(EM
4.00A
)
7V3P
(EM
3.60A
)
DBSNP
rs121908278
rs121908259
rs80356663
rs121908272
rs80356664
rs80356664
rs121918101
rs121908273
rs80356666
rs121908260
rs80356667
rs80356668
rs80356668
rs148685531
rs121908261
rs121908279
rs121908274
rs80356669
rs28933985
rs28933985
rs80356670
rs121918102
rs80356671
rs80356671
rs121908276
rs121908277
rs80356672
Subcellular location [CC]
Secreted.
Mouse PG classification
NA
click here
to return to the previous page
