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Gene Information
Gene Name
INS
Organism
Homo sapiens (Human)
Gene Length
110
Protein Names
Insulin [Cleaved into: Insulin B chain; Insulin A chain]
Target Name
insulin
Target Type
Successful target
Gene Age
3 ( ENSG00000254647 )
Evolutionary Stage
Vertebrata
AlphaFoldDB
P01308
Gene Card
INS
Uniprot ID
P01308
Pfam
PF00049
In ASD
yes
Allosteric Prediction
yes (0.999888157)
Ortholog in Animals
Alpaca_ INS ( ortholog_one2one )
Dog_ INS ( ortholog_one2one )
GuineaPig_ INS ( ortholog_one2one )
Macaque_ INS ( ortholog_one2one )
Mouse_ Ins1 ( ortholog_one2many )
Mouse_ Ins2 ( ortholog_one2many )
Pig_ INS ( ortholog_one2one )
Rat_ Ins1 ( ortholog_one2many )
Rat_ Ins2 ( ortholog_one2many )
Rabbit_ INS ( ortholog_one2one )
Ohnologs
NA
Paralogs
IGF1, IGF2
Tissue
pancreas
Tissue Specificity
NA
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.001578(Rat);0.019048(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1A7F
(NMR
-
)
1AI0
(NMR
-
)
1AIY
(NMR
-
)
1B9E
(X-ray
2.50A
)
1BEN
(X-ray
1.40A
)
1EFE
(NMR
-
)
1EV3
(X-ray
1.78A
)
1EV6
(X-ray
1.90A
)
1EVR
(X-ray
1.90A
)
1FU2
(X-ray
3.24A
)
1FUB
(X-ray
3.09A
)
1G7A
(X-ray
1.20A
)
1G7B
(X-ray
1.30A
)
1GUJ
(X-ray
1.62A
)
1HIQ
(NMR
-
)
1HIS
(NMR
-
)
1HIT
(NMR
-
)
1HLS
(NMR
-
)
1HTV
(X-ray
1.90A
)
1HUI
(NMR
-
)
1IOG
(NMR
-
)
1IOH
(NMR
-
)
1J73
(X-ray
2.00A
)
1JCA
(X-ray
2.50A
)
1JCO
(NMR
-
)
1JK8
(X-ray
2.40A
)
1K3M
(NMR
-
)
1KMF
(NMR
-
)
1LKQ
(NMR
-
)
1LPH
(X-ray
2.30A
)
1MHI
(NMR
-
)
1MHJ
(NMR
-
)
1MSO
(X-ray
1.00A
)
1OS3
(X-ray
1.95A
)
1OS4
(X-ray
2.25A
)
1Q4V
(X-ray
2.00A
)
1QIY
(X-ray
2.30A
)
1QIZ
(X-ray
2.00A
)
1QJ0
(X-ray
2.40A
)
1RWE
(X-ray
1.80A
)
1SF1
(NMR
-
)
1SJT
(NMR
-
)
1SJU
(NMR
-
)
1T0C
(NMR
-
)
1T1K
(NMR
-
)
1T1P
(NMR
-
)
1T1Q
(NMR
-
)
1TRZ
(X-ray
1.60A
)
1TYL
(X-ray
1.90A
)
1TYM
(X-ray
1.90A
)
1UZ9
(X-ray
1.60A
)
1VKT
(NMR
-
)
1W8P
(X-ray
2.08A
)
1XDA
(X-ray
1.80A
)
1XGL
(NMR
-
)
1XW7
(X-ray
2.30A
)
1ZEG
(X-ray
1.60A
)
1ZEH
(X-ray
1.50A
)
1ZNJ
(X-ray
2.00A
)
2AIY
(NMR
-
)
2C8Q
(X-ray
1.95A
)
2C8R
(X-ray
1.50A
)
2CEU
(X-ray
1.80A
)
2G54
(X-ray
2.25A
)
2G56
(X-ray
2.20A
)
2H67
(NMR
-
)
2HH4
(NMR
-
)
2HHO
(NMR
-
)
2HIU
(NMR
-
)
2JMN
(NMR
-
)
2JUM
(NMR
-
)
2JUU
(NMR
-
)
2JUV
(NMR
-
)
2JV1
(NMR
-
)
2JZQ
(NMR
-
)
2K91
(NMR
-
)
2K9R
(NMR
-
)
2KJJ
(NMR
-
)
2KJU
(NMR
-
)
2KQP
(NMR
-
)
2KQQ
(NMR
-
)
2KXK
(NMR
-
)
2L1Y
(NMR
-
)
2L1Z
(NMR
-
)
2LGB
(NMR
-
)
2LWZ
(NMR
-
)
2M1D
(NMR
-
)
2M1E
(NMR
-
)
2M2M
(NMR
-
)
2M2N
(NMR
-
)
2M2O
(NMR
-
)
2M2P
(NMR
-
)
2MLI
(NMR
-
)
2MPG
(NMR
-
)
2MPI
(NMR
-
)
2MVC
(NMR
-
)
2MVD
(NMR
-
)
2N2V
(NMR
-
)
2N2W
(NMR
-
)
2N2X
(NMR
-
)
2OLY
(X-ray
1.70A
)
2OLZ
(X-ray
1.70A
)
2OM0
(X-ray
2.05A
)
2OM1
(X-ray
1.97A
)
2OMG
(X-ray
1.52A
)
2OMH
(X-ray
1.36A
)
2OMI
(X-ray
2.24A
)
2OMQ
(X-ray
2.00A
)
2QIU
(X-ray
2.00A
)
2R34
(X-ray
2.25A
)
2R35
(X-ray
2.08A
)
2R36
(X-ray
2.00A
)
2RN5
(NMR
-
)
2VJZ
(X-ray
1.80A
)
2VK0
(X-ray
2.20A
)
2W44
(X-ray
2.00A
)
2WBY
(X-ray
2.60A
)
2WC0
(X-ray
2.80A
)
2WRU
(X-ray
1.57A
)
2WRV
(X-ray
2.15A
)
2WRW
(X-ray
2.41A
)
2WRX
(X-ray
1.50A
)
2WS0
(X-ray
2.10A
)
2WS1
(X-ray
1.60A
)
2WS4
(X-ray
1.90A
)
2WS6
(X-ray
1.50A
)
2WS7
(X-ray
2.59A
)
3AIY
(NMR
-
)
3BXQ
(X-ray
1.30A
)
3E7Y
(X-ray
1.60A
)
3E7Z
(X-ray
1.70A
)
3EXX
(X-ray
1.35A
)
3FQ9
(X-ray
1.35A
)
3HYD
(X-ray
1.00A
)
3I3Z
(X-ray
1.60A
)
3I40
(X-ray
1.85A
)
3ILG
(X-ray
1.90A
)
3INC
(X-ray
1.85A
)
3IR0
(X-ray
2.20A
)
3JSD
(X-ray
2.50A
)
3KQ6
(X-ray
1.90A
)
3P2X
(X-ray
2.00A
)
3P33
(X-ray
2.30A
)
3Q6E
(X-ray
2.05A
)
3ROV
(X-ray
2.30A
)
3TT8
(X-ray
1.12A
)
3U4N
(X-ray
1.98A
)
3UTQ
(X-ray
1.67A
)
3UTS
(X-ray
2.71A
)
3UTT
(X-ray
2.60A
)
3V19
(X-ray
2.00A
)
3V1G
(X-ray
2.20A
)
3W11
(X-ray
3.90A
)
3W12
(X-ray
4.30A
)
3W13
(X-ray
4.30A
)
3W7Y
(X-ray
0.92A
)
3W7Z
(X-ray
1.15A
)
3W80
(X-ray
1.40A
)
3ZI3
(X-ray
1.70A
)
3ZQR
(X-ray
1.90A
)
3ZS2
(X-ray
1.97A
)
3ZU1
(X-ray
1.60A
)
4AIY
(NMR
-
)
4AJX
(X-ray
1.20A
)
4AJZ
(X-ray
1.80A
)
4AK0
(X-ray
2.28A
)
4AKJ
(X-ray
2.01A
)
4CXL
(X-ray
1.50A
)
4CXN
(X-ray
1.70A
)
4CY7
(X-ray
1.40A
)
4EFX
(X-ray
1.98A
)
4EWW
(X-ray
2.30A
)
4EWX
(X-ray
2.20A
)
4EWZ
(X-ray
1.79A
)
4EX0
(X-ray
1.86A
)
4EX1
(X-ray
1.66A
)
4EXX
(X-ray
1.55A
)
4EY1
(X-ray
1.47A
)
4EY9
(X-ray
1.47A
)
4EYD
(X-ray
1.47A
)
4EYN
(X-ray
1.53A
)
4EYP
(X-ray
1.59A
)
4F0N
(X-ray
1.68A
)
4F0O
(X-ray
1.67A
)
4F1A
(X-ray
1.80A
)
4F1B
(X-ray
1.59A
)
4F1C
(X-ray
1.70A
)
4F1D
(X-ray
1.64A
)
4F1F
(X-ray
1.68A
)
4F1G
(X-ray
1.64A
)
4F4T
(X-ray
1.64A
)
4F4V
(X-ray
1.64A
)
4F51
(X-ray
1.64A
)
4F8F
(X-ray
1.68A
)
4FG3
(X-ray
2.00A
)
4FKA
(X-ray
1.08A
)
4GBC
(X-ray
1.78A
)
4GBI
(X-ray
2.50A
)
4GBK
(X-ray
2.40A
)
4GBL
(X-ray
2.50A
)
4GBN
(X-ray
1.87A
)
4IUZ
(X-ray
1.60A
)
4IYD
(X-ray
1.66A
)
4IYF
(X-ray
1.80A
)
4NIB
(X-ray
1.40A
)
4OGA
(X-ray
3.50A
)
4P65
(X-ray
1.50A
)
4RXW
(X-ray
1.73A
)
4UNE
(X-ray
1.59A
)
4UNG
(X-ray
1.81A
)
4UNH
(X-ray
2.75A
)
4WDI
(X-ray
2.31A
)
4XC4
(X-ray
1.50A
)
4Y19
(X-ray
2.50A
)
4Y1A
(X-ray
4.00A
)
4Z76
(X-ray
1.88A
)
4Z77
(X-ray
1.85A
)
4Z78
(X-ray
2.30A
)
5AIY
(NMR
-
)
5BOQ
(X-ray
1.70A
)
5BPO
(X-ray
1.90A
)
5BQQ
(X-ray
1.54A
)
5BTS
(X-ray
1.77A
)
5C0D
(X-ray
1.68A
)
5CJO
(X-ray
3.29A
)
5CNY
(X-ray
1.70A
)
5CO2
(X-ray
1.70A
)
5CO6
(X-ray
1.80A
)
5CO9
(X-ray
1.92A
)
5E7W
(X-ray
0.95A
)
5EMS
(X-ray
2.30A
)
5EN9
(X-ray
1.50A
)
5ENA
(X-ray
1.35A
)
5HPR
(X-ray
1.33A
)
5HPU
(X-ray
2.20A
)
5HQI
(X-ray
0.97A
)
5HRQ
(X-ray
1.28A
)
5HYJ
(X-ray
3.06A
)
5MAM
(X-ray
2.20A
)
5MHD
(NMR
-
)
5MT3
(X-ray
2.02A
)
5MT9
(X-ray
1.88A
)
5MWQ
(NMR
-
)
5T7R
(X-ray
1.55A
)
5UDP
(X-ray
1.35A
)
5UOZ
(X-ray
1.17A
)
5UQA
(X-ray
1.31A
)
5URT
(X-ray
1.18A
)
5URU
(X-ray
2.41A
)
5USP
(X-ray
1.17A
)
5USS
(X-ray
2.06A
)
5USV
(X-ray
1.30A
)
5UU2
(X-ray
1.22A
)
5UU3
(X-ray
2.25A
)
5UU4
(X-ray
1.97A
)
5VIZ
(X-ray
1.70A
)
5WBT
(NMR
-
)
5WDM
(X-ray
2.80A
)
5WOB
(X-ray
3.95A
)
6B3Q
(EM
3.70A
)
6B70
(EM
3.70A
)
6BFC
(EM
3.70A
)
6CE7
(EM
7.40A
)
6CE9
(EM
4.30A
)
6CEB
(EM
4.70A
)
6CK2
(X-ray
2.25A
)
6GNQ
(X-ray
2.20A
)
6GV0
(X-ray
1.26A
)
6H3M
(X-ray
1.82A
)
6HN5
(EM
3.20A
)
6JK8
(EM
4.70A
)
6JR3
(EM
14.50A
)
6K59
(NMR
-
)
6NWV
(X-ray
1.60A
)
6O17
(X-ray
1.58A
)
6P4Z
(X-ray
1.80A
)
6S34
(X-ray
1.35A
)
6S4I
(X-ray
1.51A
)
6S4J
(X-ray
1.50A
)
6SOF
(EM
4.30A
)
6TC2
(X-ray
1.36A
)
6TYH
(X-ray
1.60A
)
6U46
(NMR
-
)
6VEP
(X-ray
2.90A
)
6VER
(X-ray
1.05A
)
6VES
(X-ray
1.85A
)
6VET
(X-ray
1.46A
)
6X4X
(NMR
-
)
6Z7W
(X-ray
2.42A
)
6Z7Y
(X-ray
2.20A
)
7BW7
(EM
4.10A
)
7BW8
(EM
3.80A
)
7BWA
(EM
4.90A
)
7JP3
(X-ray
1.95A
)
7KD6
(X-ray
2.60A
)
7MD4
(EM
4.50A
)
7MD5
(EM
5.20A
)
7MQO
(EM
3.40A
)
7MQR
(EM
4.10A
)
7MQS
(EM
4.40A
)
7NHU
(X-ray
1.40A
)
7PG0
(EM
7.60A
)
7PG2
(EM
6.70A
)
7PG3
(EM
7.30A
)
7PG4
(EM
9.10A
)
7QGF
(X-ray
1.20A
)
7QID
(EM
5.00A
)
7RKD
(X-ray
1.25A
)
7RZE
(EM
3.30A
)
7RZF
(EM
3.40A
)
7RZI
(EM
3.00A
)
7S4Y
(X-ray
1.71A
)
7SL1
(EM
3.40A
)
7SL2
(EM
3.60A
)
7SL3
(EM
3.40A
)
7SL4
(EM
5.00A
)
7SL6
(EM
3.70A
)
7SL7
(EM
3.10A
)
7STH
(EM
3.50A
)
7STI
(EM
4.90A
)
7STJ
(EM
4.40A
)
7STK
(EM
4.00A
)
7V3P
(EM
3.60A
)
DBSNP
rs121908278
rs121908259
rs80356663
rs121908272
rs80356664
rs80356664
rs121918101
rs121908273
rs80356666
rs121908260
rs80356667
rs80356668
rs80356668
rs148685531
rs121908261
rs121908279
rs121908274
rs80356669
rs28933985
rs28933985
rs80356670
rs121918102
rs80356671
rs80356671
rs121908276
rs121908277
rs80356672
Subcellular location [CC]
Secreted.
Mouse PG classification
NA
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