Gene Information
Gene NameINPP5K
OrganismHomo sapiens (Human)
Gene Length448
Protein NamesInositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Skeletal muscle and kidney-enriched inositol phosphatase)
Target NameNA
Target TypeNA
Gene Age>4290 ( ENSG00000132376 )
Evolutionary StageEukaryota
AlphaFoldDBQ9BT40
Gene CardINPP5K
Uniprot IDQ9BT40
PfamPF03372; PF17751
In ASDno
Allosteric Predictionno (-0.109206415)
Ortholog in AnimalsAlpaca_ INPP5K ( ortholog_one2one )
Dog_ INPP5K ( ortholog_one2one )
GuineaPig_ INPP5K ( ortholog_one2one )
Macaque_ INPP5K ( ortholog_one2one )
Mouse_ Inpp5k ( ortholog_one2one )
Pig_ INPP5K ( ortholog_one2one )
Rat_ Inpp5k ( ortholog_one2one )
Rabbit_ INPP5K ( ortholog_one2one )
OhnologsINPP5J
ParalogsSH2D1B, SH2D1A, FIG4, INPP5E, SYNJ2, SACM1L, OCRL, INPP5D, INPPL1, INPP5F, INPP5J, SYNJ1, INPP5B
TissueNA
Tissue SpecificityUbiquitously expressed with highest levels in skeletal muscle, heart and kidney. {ECO:0000269|PubMed:10753883}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs750781027  rs1060505038  rs1060505039  rs749383757  rs761612652  rs766046008  rs993849342 
Subcellular location [CC]Endoplasmic reticulum {ECO:0000269|PubMed:12536145, ECO:0000269|PubMed:26940976, ECO:0000269|PubMed:28190456}. Cytoplasm {ECO:0000269|PubMed:10753883}. Note=Following stimulation with EGF, translocates to membrane ruffles (PubMed:12536145, PubMed:26940976). Concentrated at the periphery of the nucleus (PubMed:10753883). {ECO:0000269|PubMed:10753883, ECO:0000269|PubMed:12536145, ECO:0000269|PubMed:26940976}.
Mouse PG classificationNA
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