Gene Information
Gene NameRAD21
OrganismHomo sapiens (Human)
Gene Length631
Protein NamesDouble-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)]
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000164754 )
Evolutionary StageEukaryota
AlphaFoldDBO60216
Gene CardRAD21
Uniprot IDO60216
PfamPF04824; PF04825
In ASDno
Allosteric Predictionyes (0.181651193)
Ortholog in AnimalsAlpaca_ RAD21 ( ortholog_one2one )
Dog_ RAD21 ( ortholog_one2one )
GuineaPig_ RAD21 ( ortholog_one2one )
Macaque_ RAD21 ( ortholog_one2one )
Mouse_ Rad21 ( ortholog_one2one )
Pig_ RAD21 ( ortholog_one2one )
Rat_ Rad21 ( ortholog_one2one )
Rabbit_ RAD21 ( ortholog_one2one )
OhnologsSNPH
ParalogsRAD21L1, REC8
TissueNA
Tissue SpecificityExpressed in the gut (at protein level). {ECO:0000269|PubMed:25575569}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.151948(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4PJU  (X-ray  3.05A  )  4PJW  (X-ray  2.85A  )  4PK7  (X-ray  2.95A  )  6QNX  (X-ray  2.70A  )  6RRC  (X-ray  2.37A  )  6RRK  (X-ray  3.17A  )  6WG3  (EM  5.30A  )  6WGE  (EM  3.90A  ) 
DBSNP rs387907212  rs755168088  rs387907213  rs775266057 
Subcellular location [CC][Double-strand-break repair protein rad21 homolog]: Nucleus {ECO:0000269|PubMed:11073952, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:12417729}. Nucleus matrix {ECO:0000269|PubMed:10623634, ECO:0000269|PubMed:11590136}. Chromosome {ECO:0000269|PubMed:11073952, ECO:0000269|PubMed:11590136}. Chromosome, centromere {ECO:0000269|PubMed:11073952}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11073952, ECO:0000269|PubMed:11590136}. Note=Associates with chromatin (PubMed:11590136, PubMed:11073952). Before prophase, scattered along chromosome arms (PubMed:11073952). During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (PubMed:11931760). A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase/ESPL1 leads to the dissociation of cohesin from chromosomes and chromosome separation (PubMed:11073952, PubMed:11509732). {ECO:0000269|PubMed:11073952, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:11931760}.;
[64-kDa C-terminal product]: Cytoplasm, cytosol {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}. Nucleus {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}.
Mouse PG classificationLPG
click here to return to the previous page