Gene Information
Gene NameDNAH1
OrganismHomo sapiens (Human)
Gene Length4265
Protein NamesDynein axonemal heavy chain 1 (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000114841 )
Evolutionary StageEukaryota
AlphaFoldDBNA
Gene CardDNAH1
Uniprot IDQ9P2D7
PfamPF12774; PF12780; PF12781; PF17857; PF18198; PF08393; PF17852; PF18199; PF03028; PF12777
In ASDno
Allosteric Predictionno (-1.005044717)
Ortholog in AnimalsAlpaca_ DNAH1 ( ortholog_one2one )
Dog_ DNAH1 ( ortholog_one2one )
GuineaPig_ DNAH1 ( ortholog_one2one )
Macaque_ DNAH1 ( ortholog_one2one )
Mouse_ Dnah1 ( ortholog_one2one )
Pig_ DNAH1 ( ortholog_one2one )
Rat_ Dnah1 ( ortholog_one2one )
Rabbit_ DNAH1 ( ortholog_one2one )
OhnologsDNAH5, DNAH8, DNAH6
ParalogsDNAH3, DNHD1, DNAH14, DNAH9, DYNC1H1, DNAH12, DNAH2, DNAH17, DYNC2H1, DNAH7, DNAH10, DNAH6, DNAH5, DNAH8, DNAH11
TissueNA
Tissue SpecificityExpressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain (PubMed:11175280). {ECO:0000269|PubMed:11175280, ECO:0000269|PubMed:24360805, ECO:0000269|PubMed:9256245}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs10460963  rs13060192  rs544674332  rs1131692251  rs140883175  rs374644342  rs17052095  rs17052097  rs757396103  rs778635747  rs56002041  rs365048  rs748247721  rs776800142  rs765046623 
Subcellular location [CC]Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:24360805}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:E9Q8T7}.
Mouse PG classificationNA
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