| Gene Information | |
|---|---|
| Gene Name | INO80 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1556 |
| Protein Names | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000128908 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9ULG1 |
| Gene Card | INO80 |
| Uniprot ID | Q9ULG1 |
| Pfam | PF13892; PF00271; PF00176 |
| In ASD | no |
| Allosteric Prediction | no (-0.422199202) |
| Ortholog in Animals | Alpaca_ INO80 ( ortholog_one2one ) Dog_ INO80 ( ortholog_one2one ) GuineaPig_ INO80 ( ortholog_one2one ) Macaque_ INO80 ( ortholog_one2one ) Mouse_ Ino80 ( ortholog_one2one ) Pig_ INO80 ( ortholog_one2one ) Rat_ Ino80 ( ortholog_one2one ) Rabbit_ INO80 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SMARCA1, RAD54B, HLTF, HELLS, SHPRH, BTAF1, ZRANB3, SMARCA5, TTF2, SMARCA2, CHD9, SMARCAL1, CHD1L, CHD3, RAD54L2, SMARCAD1, CHD4, ATRX, CHD6, SRCAP, CHD1, CHD2, RAD54L, CHD7, CHD8, EP400, ERCC6, ERCC6L, CHD5, SMARCA4 |
| Tissue | NA |
| Tissue Specificity | According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas. {ECO:0000269|PubMed:10574462, ECO:0000269|PubMed:16298340}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6HTS (EM 4.80A ) |
| DBSNP | rs34153025 rs34178030 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20237820}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00746, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20971067}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20237820}. Chromosome {ECO:0000269|PubMed:20237820}. Note=Localizes to the cytoplasm in quiescent cell (PubMed:20237820). Associates with spindle microtubules during mitosis (PubMed:20237820). Colocalizes with PCNA at replication forks during S-phase (PubMed:20237820). Recruited to DNA damage sites in a ACTR8-dependent manner (PubMed:20971067). {ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20971067}. |
| Mouse PG classification | NA |
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