| Gene Information | |
|---|---|
| Gene Name | MCH6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 416 |
| Protein Names | Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P55211 |
| Gene Card | CASP9 |
| Uniprot ID | P55211 |
| Pfam | PF00619 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. {ECO:0000269|PubMed:16857965}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JXQ (X-ray 2.80A ) 1NW9 (X-ray 2.40A ) 2AR9 (X-ray 2.80A ) 3D9T (X-ray 1.50A ) 3V3K (X-ray 3.49A ) 3YGS (X-ray 2.50A ) 4RHW (X-ray 2.10A ) 5JUY (EM 4.10A ) 5WVC (X-ray 2.99A ) 5WVE (EM 4.40A ) |
| DBSNP | rs1052571 rs4646008 rs2308941 rs2308938 rs2020897 rs1132312 rs2308950 rs2308949 rs9282624 rs2308939 rs1052576 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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