| Gene Information | |
|---|---|
| Gene Name | IMPG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1241 |
| Protein Names | Interphotoreceptor matrix proteoglycan 2 (Interphotoreceptor matrix proteoglycan of 200 kDa) (IPM 200) (Sialoprotein associated with cones and rods proteoglycan) (Spacrcan) |
| Target Name | interphotoreceptor matrix proteoglycan 2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000081148 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BZV3 |
| Gene Card | IMPG2 |
| Uniprot ID | Q9BZV3 |
| Pfam | PF01390 |
| In ASD | no |
| Allosteric Prediction | no (-1.442753384) |
| Ortholog in Animals | Alpaca_ IMPG2 ( ortholog_one2one ) Dog_ IMPG2 ( ortholog_one2one ) GuineaPig_ IMPG2 ( ortholog_one2one ) Macaque_ IMPG2 ( ortholog_one2one ) Mouse_ Impg2 ( ortholog_one2one ) Pig_ IMPG2 ( ortholog_one2one ) Rat_ Impg2 ( ortholog_one2one ) Rabbit_ IMPG2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IMPG1 |
| Tissue | oviduct, pineal.gland |
| Tissue Specificity | Expressed in the retina (at protein level) (PubMed:10702256, PubMed:29777959). Expressed by photoreceptors of the interphotoreceptor matrix (IPM) surrounding both rods and cones (at protein level) (PubMed:10542133, PubMed:29777959). IPM occupies the subretinal space between the apices of the retinal pigment epithelium and the neural retina (PubMed:10542133). Expressed in the pineal gland (at protein level) (PubMed:10702256). {ECO:0000269|PubMed:10542133, ECO:0000269|PubMed:10702256, ECO:0000269|PubMed:29777959}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs201893545 rs1706811719 rs34375459 rs571391 rs116450347 rs713993049 |
| Subcellular location [CC] | Photoreceptor outer segment membrane {ECO:0000269|PubMed:29777959}; Single-pass type I membrane protein {ECO:0000255}. Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:Q80XH2}; Single-pass type I membrane protein {ECO:0000255}. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000269|PubMed:10702256}. |
| Mouse PG classification | NA |
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