Gene Information
Gene NameIMPDH1
OrganismHomo sapiens (Human)
Gene Length514
Protein NamesInosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I)
Target Nameinosine-5'-monophosphate dehydrogenase 1
Target TypeSuccessful target
Gene Age645 ( ENSG00000106348 )
Evolutionary StageCellular_organisms
AlphaFoldDBP20839
Gene CardIMPDH1
Uniprot IDP20839
PfamPF00571; PF00478
In ASDyes
Allosteric Predictionyes (1.000409994)
Ortholog in AnimalsAlpaca_ IMPDH1 ( ortholog_one2one )
Dog_ IMPDH1 ( ortholog_one2one )
GuineaPig_ IMPDH1 ( ortholog_one2one )
Macaque_ IMPDH1 ( ortholog_one2one )
Mouse_ Impdh1 ( ortholog_one2one )
Pig_ IMPDH1 ( ortholog_one2one )
Rat_ Impdh1 ( ortholog_one2one )
Rabbit_ IMPDH1 ( ortholog_one2one )
OhnologsIMPDH2
ParalogsIMPDH2, GMPR2, GMPR
TissueNA
Tissue SpecificityIMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.003571(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1JCN  (X-ray  2.50A  )  7RER  (EM  2.60A  )  7RES  (EM  3.05A  )  7RFE  (EM  2.60A  )  7RFF  (EM  2.70A  )  7RFG  (EM  2.60A  )  7RFH  (EM  3.70A  )  7RFI  (EM  2.60A  )  7RGD  (EM  3.00A  )  7RGI  (EM  3.60A  )  7RGL  (EM  2.40A  )  7RGM  (EM  2.80A  )  7RGQ  (EM  3.90A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}.
Mouse PG classificationNA
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