| Gene Information | |
|---|---|
| Gene Name | IMPD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 514 |
| Protein Names | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P12268 |
| Gene Card | IMPDH2 |
| Uniprot ID | P12268 |
| Pfam | PF00571; PF00478 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1B3O (X-ray 2.90A ) 1NF7 (X-ray 2.65A ) 1NFB (X-ray 2.90A ) 6I0M (X-ray 2.57A ) 6I0O (X-ray 2.62A ) 6U8E (EM 3.03A ) 6U8N (EM 3.29A ) 6U8R (EM 3.91A ) 6U8S (EM 3.14A ) 6U9O (EM 3.36A ) 6UA2 (EM 4.20A ) 6UA4 (EM 3.65A ) 6UA5 (EM 3.79A ) 6UAJ (EM 3.84A ) 6UC2 (EM 4.48A ) 6UDO (EM 3.21A ) 6UDP (EM 2.95A ) 6UDQ (EM 3.27A ) |
| DBSNP | rs121434586 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000269|PubMed:14766016}. Cytoplasm, cytosol {ECO:0000269|PubMed:31337707}. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion. {ECO:0000269|PubMed:24477477, ECO:0000269|PubMed:31337707}. |
| Mouse PG classification | NA |
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