| Gene Information | |
|---|---|
| Gene Name | CFAP221 |
| Organism | Homo sapiens (Human) |
| Gene Length | 840 |
| Protein Names | Cilia- and flagella-associated protein 221 (Primary ciliary dyskinesia protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000163075 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q4G0U5 |
| Gene Card | CFAP221 |
| Uniprot ID | Q4G0U5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.800350187) |
| Ortholog in Animals | Alpaca_ CFAP221 ( ortholog_one2one ) Dog_ CFAP221 ( ortholog_one2one ) Macaque_ CFAP221 ( ortholog_one2one ) Mouse_ Cfap221 ( ortholog_one2one ) Pig_ CFAP221 ( ortholog_one2one ) Rat_ Cfap221 ( ortholog_one2one ) Rabbit_ CFAP221 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | oviduct, testis |
| Tissue Specificity | Expressed in ciliated respiratory epithelial cells and brain ependymal cells (at protein level). {ECO:0000269|PubMed:18039845}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2272058 rs11686014 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:18039845}. Cytoplasm {ECO:0000250|UniProtKB:A9Q751}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A9Q751}. Note=Localizes to the manchette in elongating spermatids in a SPAG17-dependent manner. {ECO:0000250|UniProtKB:A9Q751}. |
| Mouse PG classification | NA |
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