| Gene Information | |
|---|---|
| Gene Name | RAMP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 148 |
| Protein Names | Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3) |
| Target Name | receptor activity-modifying protein 3 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000122679 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O60896 |
| Gene Card | RAMP3 |
| Uniprot ID | O60896 |
| Pfam | PF04901 |
| In ASD | no |
| Allosteric Prediction | yes (0.22048639) |
| Ortholog in Animals | Alpaca_ RAMP3 ( ortholog_one2one ) GuineaPig_ RAMP3 ( ortholog_one2one ) Macaque_ RAMP3 ( ortholog_one2one ) Mouse_ Ramp3 ( ortholog_one2one ) Pig_ RAMP3 ( ortholog_one2one ) Rat_ Ramp3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAMP2, RAMP1 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269|PubMed:9620797}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6UUS (EM 2.40A ) 6UVA (EM 2.30A ) 7TZF (EM 2.40A ) |
| DBSNP | rs10272187 rs11550711 rs2074654 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner. |
| Mouse PG classification | NA |
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