| Gene Information | |
|---|---|
| Gene Name | ILK |
| Organism | Homo sapiens (Human) |
| Gene Length | 452 |
| Protein Names | Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK) |
| Target Name | integrin-linked protein kinase 1 |
| Target Type | Patented-recorded target |
| Gene Age | 987 ( ENSG00000166333 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13418 |
| Gene Card | ILK |
| Uniprot ID | Q13418 |
| Pfam | PF12796; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (0.542676517) |
| Ortholog in Animals | Alpaca_ ILK ( ortholog_one2one ) Dog_ ILK ( ortholog_one2one ) GuineaPig_ ILK ( ortholog_one2one ) Macaque_ ILK ( ortholog_one2one ) Mouse_ Ilk ( ortholog_one2one ) Pig_ ILK ( ortholog_one2one ) Rat_ Ilk ( ortholog_one2one ) Rabbit_ ILK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LIMK2, RIPK1, LRRK2, TNNI3K, TESK2, KSR2, MAP3K10, RIPK2, MOS, MAP3K9, MLKL, MAP3K20, ARAF, TESK1, MAP3K13, BRAF, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, KSR1, RIPK3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2KBX (NMR - ) 3F6Q (X-ray 1.60A ) 3IXE (X-ray 1.90A ) 3KMU (X-ray 1.80A ) 3KMW (X-ray 2.00A ) 3REP (X-ray 1.80A ) 4HI8 (X-ray 1.20A ) 4HI9 (X-ray 1.20A ) 6MIB (X-ray 1.80A ) |
| DBSNP | rs387907366 |
| Subcellular location [CC] | Cell junction, focal adhesion {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:12167643}. Cell membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:11402068}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O55222}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:11402068}. |
| Mouse PG classification | NA |
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