| Gene Information | |
|---|---|
| Gene Name | ILDR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 639 |
| Protein Names | Immunoglobulin-like domain-containing receptor 2 (Angulin-3) |
| Target Name | ig-like domain-containing receptor 2 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000143195 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q71H61 |
| Gene Card | ILDR2 |
| Uniprot ID | Q71H61 |
| Pfam | PF05624 |
| In ASD | no |
| Allosteric Prediction | no (-0.616771628) |
| Ortholog in Animals | Alpaca_ ILDR2 ( ortholog_one2one ) Dog_ ILDR2 ( ortholog_one2one ) GuineaPig_ ILDR2 ( ortholog_one2one ) Macaque_ ILDR2 ( ortholog_one2one ) Mouse_ Ildr2 ( ortholog_one2one ) Pig_ ILDR2 ( ortholog_one2one ) Rat_ Ildr2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LSR, ILDR1 |
| Tissue | NA |
| Tissue Specificity | Expressed in testis, brain, pituitary, colon, heart, nerves, prostate, esophagus, lung liver and small intestine (PubMed:29431694). Highly expressed in macrophages, also expressed in monocytes and at low levels in NK and NKT cells (at protein level) (PubMed:29431694). {ECO:0000269|PubMed:29431694}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs33958744 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:B5TVM2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:B5TVM2}. Cell junction, tight junction {ECO:0000250|UniProtKB:B5TVM2}. Nucleus {ECO:0000250|UniProtKB:B5TVM2}. |
| Mouse PG classification | NA |
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