| Gene Information | |
|---|---|
| Gene Name | IL7R |
| Organism | Homo sapiens (Human) |
| Gene Length | 459 |
| Protein Names | Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) |
| Target Name | interleukin 7 receptor alpha |
| Target Type | Clinical trial target |
| Gene Age | 332 ( ENSG00000168685 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P16871 |
| Gene Card | IL7R |
| Uniprot ID | P16871 |
| Pfam | PF00041; PF18447 |
| In ASD | no |
| Allosteric Prediction | yes (0.287455008) |
| Ortholog in Animals | Alpaca_ IL7R ( ortholog_one2one ) Dog_ IL7R ( ortholog_one2one ) GuineaPig_ IL7R ( ortholog_one2one ) Macaque_ IL7R ( ortholog_one2one ) Mouse_ Il7r ( ortholog_one2one ) Pig_ IL7R ( ortholog_one2one ) Rat_ Il7r ( ortholog_one2one ) Rabbit_ IL7R ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MPL, IL4R, IL2RB, IL9R, IL21R, CSF2RB, EPOR |
| Tissue | lung, lymph.node, small.intestine.Peyers.patch, spleen |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3DI2 (X-ray 2.70A ) 3DI3 (X-ray 2.90A ) 3UP1 (X-ray 2.15A ) 5J11 (X-ray 2.56A ) 6P50 (X-ray 2.90A ) 6P67 (X-ray 2.90A ) 7OPB (X-ray 2.14A ) |
| DBSNP | rs1494558 rs11567735 rs104893894 rs1494555 rs6897932 rs3194051 rs2229232 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Secreted. |
| Mouse PG classification | NA |
| click here to return to the previous page | |