| Gene Information | |
|---|---|
| Gene Name | IL6R |
| Organism | Homo sapiens (Human) |
| Gene Length | 468 |
| Protein Names | Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)] |
| Target Name | interleukin-6 receptor subunit alpha |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000160712 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P08887 |
| Gene Card | IL6R |
| Uniprot ID | P08887 |
| Pfam | PF00047; PF09240 |
| In ASD | no |
| Allosteric Prediction | yes (0.241774561) |
| Ortholog in Animals | Alpaca_ IL6R ( ortholog_one2one ) Dog_ IL6R ( ortholog_one2one ) GuineaPig_ IL6R ( ortholog_one2one ) Macaque_ IL6R ( ortholog_one2one ) Mouse_ Il6ra ( ortholog_one2one ) Pig_ IL6R ( ortholog_one2one ) Rat_ Il6r ( ortholog_one2one ) Rabbit_ IL6R ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR, LEPR |
| Tissue | NA |
| Tissue Specificity | [Isoform 2]: Expressed in peripheral blood mononuclear cells and weakly found in urine and serum. 1%-20% of the total sIL6R in plasma is generated by alternative splicing (PubMed:28060820). {ECO:0000269|PubMed:28060820}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1N26 (X-ray 2.40A ) 1P9M (X-ray 3.65A ) 2ARW (NMR - ) 5FUC (X-ray 2.70A ) 7DC8 (X-ray 2.76A ) |
| DBSNP | rs1689606931 rs2228145 rs2228146 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P22272}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:28060820}.; [Soluble interleukin-6 receptor subunit alpha]: Secreted {ECO:0000269|PubMed:28060820}. |
| Mouse PG classification | NA |
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