| Gene Information | |
|---|---|
| Gene Name | IL6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 212 |
| Protein Names | Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2) |
| Target Name | interleukin-6 |
| Target Type | Successful target |
| Gene Age | >4290 ( ENSG00000136244 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P05231 |
| Gene Card | IL6 |
| Uniprot ID | P05231 |
| Pfam | PF00489 |
| In ASD | no |
| Allosteric Prediction | yes (1.377094876) |
| Ortholog in Animals | Alpaca_ IL6 ( ortholog_one2many ) Dog_ IL6 ( ortholog_one2one ) Macaque_ IL6 ( ortholog_one2one ) Mouse_ Il6 ( ortholog_one2one ) Pig_ IL6 ( ortholog_one2one ) Rat_ Il6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | greater.omentum |
| Tissue Specificity | Produced by skeletal muscle. {ECO:0000269|PubMed:11080265}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ALU (X-ray 1.90A ) 1IL6 (NMR - ) 1P9M (X-ray 3.65A ) 2IL6 (NMR - ) 4CNI (X-ray 2.20A ) 4J4L (X-ray 2.30A ) 4NI7 (X-ray 2.40A ) 4NI9 (X-ray 2.55A ) 4O9H (X-ray 2.42A ) 4ZS7 (X-ray 2.93A ) 5FUC (X-ray 2.70A ) 7NXZ (X-ray 2.00A ) |
| DBSNP | rs2069830 rs13306435 rs2069860 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11080265}. |
| Mouse PG classification | NA |
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