| Gene Information | |
|---|---|
| Gene Name | IL5RA |
| Organism | Homo sapiens (Human) |
| Gene Length | 420 |
| Protein Names | Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125) |
| Target Name | interleukin 5 receptor alpha |
| Target Type | Successful target |
| Gene Age | 424 ( ENSG00000091181 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q01344 |
| Gene Card | IL5RA |
| Uniprot ID | Q01344 |
| Pfam | PF09240 |
| In ASD | no |
| Allosteric Prediction | yes (0.104968617) |
| Ortholog in Animals | Alpaca_ IL5RA ( ortholog_one2one ) Dog_ IL5RA ( ortholog_one2one ) GuineaPig_ Il5ra ( ortholog_one2one ) Macaque_ IL5RA ( ortholog_one2one ) Mouse_ Il5ra ( ortholog_one2one ) Pig_ IL5RA ( ortholog_one2one ) Rat_ Il5ra ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, EBI3, PRLR, LEPR |
| Tissue | NA |
| Tissue Specificity | Expressed on eosinophils and basophils. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OBX (X-ray 1.35A ) 1OBZ (X-ray 1.69A ) 3QT2 (X-ray 2.55A ) 3VA2 (X-ray 2.70A ) 6H41 (X-ray 2.75A ) |
| DBSNP | rs2290610 rs17879690 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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