| Gene Information | |
|---|---|
| Gene Name | DCTN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 460 |
| Protein Names | Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000132912 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UJW0 |
| Gene Card | DCTN4 |
| Uniprot ID | Q9UJW0 |
| Pfam | PF05502 |
| In ASD | no |
| Allosteric Prediction | yes (0.079763305) |
| Ortholog in Animals | Alpaca_ DCTN4 ( ortholog_one2one ) Dog_ DCTN4 ( ortholog_one2one ) GuineaPig_ DCTN4 ( ortholog_one2one ) Macaque_ DCTN4 ( ortholog_one2one ) Mouse_ Dctn4 ( ortholog_one2one ) Pig_ DCTN4 ( ortholog_one2one ) Rat_ Dctn4 ( ortholog_one2one ) Rabbit_ DCTN4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.388500(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11550931 rs35772018 rs11954652 rs3733923 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10671518}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10671518}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q9QUR2}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9QUR2}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q8CBY8}. Note=Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (PubMed:10671518). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (By similarity). {ECO:0000250|UniProtKB:Q8CBY8, ECO:0000250|UniProtKB:Q9QUR2, ECO:0000269|PubMed:10671518}. |
| Mouse PG classification | NA |
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