| Gene Information | |
|---|---|
| Gene Name | IL4R |
| Organism | Homo sapiens (Human) |
| Gene Length | 825 |
| Protein Names | Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)] |
| Target Name | interleukin 4 receptor alpha |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000077238 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P24394 |
| Gene Card | IL4R |
| Uniprot ID | P24394 |
| Pfam | PF09238 |
| In ASD | no |
| Allosteric Prediction | yes (0.53839474) |
| Ortholog in Animals | Alpaca_ IL4R ( ortholog_one2one ) Dog_ IL4R ( ortholog_one2one ) GuineaPig_ IL4R ( ortholog_one2one ) Macaque_ IL4R ( ortholog_one2one ) Mouse_ Il4ra ( ortholog_one2one ) Pig_ IL4R ( ortholog_one2one ) Rat_ Il4r ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MPL, IL2RB, IL7R, IL9R, IL21R, CSF2RB, EPOR |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are highly expressed in activated T-cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IAR (X-ray 2.30A ) 1IRS (NMR - ) 3BPL (X-ray 2.93A ) 3BPN (X-ray 3.02A ) 3BPO (X-ray 3.00A ) 5E4E (X-ray 3.00A ) 6OEL (X-ray 3.10A ) 6WGL (X-ray 2.82A ) |
| DBSNP | rs1805010 rs1805010 rs1805010 rs6413500 rs1805011 rs1805012 rs1805013 rs35606110 rs34727572 rs1805015 rs1801275 rs3024677 rs3024678 rs1805016 rs1805014 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted. |
| Mouse PG classification | NA |
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