Gene Information
Gene NameIL4I1
OrganismHomo sapiens (Human)
Gene Length567
Protein NamesL-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (EC 1.4.3.25) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (hIL4I1) (Protein Fig-1) (hFIG1)
Target Namel-amino-acid oxidase
Target TypeNA
Gene Age1714 ( ENSG00000104951 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ96RQ9
Gene CardIL4I1
Uniprot IDQ96RQ9
PfamPF01593
In ASDno
Allosteric Predictionyes (0.342864653)
Ortholog in AnimalsAlpaca_ IL4I1 ( ortholog_one2one )
Dog_ IL4I1 ( ortholog_one2one )
GuineaPig_ IL4I1 ( ortholog_one2one )
Macaque_ IL4I1 ( ortholog_one2one )
Mouse_ Il4i1 ( ortholog_one2one )
Pig_ IL4I1 ( ortholog_one2one )
Rat_ Il4i1 ( ortholog_one2one )
OhnologsNA
ParalogsKDM1A, MAOA, SMOX, PPOX, KDM1B, PAOX, MAOB
Tissueappendix, testis
Tissue SpecificityPrimarily found in immune tissues, with the highest expression in lymph nodes and spleen (PubMed:12031486, PubMed:12446450). Present in germinal center macrophages and inflammatory myeloid cells and antigen-presenting cells (at protein level) (PubMed:17356132). Also present in spermatozoa (at protein level) (PubMed:25767141). Highly expressed in primary mediastinal large B-cell lymphoma, a specific subtype of diffuse large B-cell lymphoma (PubMed:12446450). Expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages (PubMed:19436310). {ECO:0000269|PubMed:12031486, ECO:0000269|PubMed:12446450, ECO:0000269|PubMed:17356132, ECO:0000269|PubMed:19436310, ECO:0000269|PubMed:25767141}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs111772144  rs2290772 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:17356132, ECO:0000269|PubMed:28891065, ECO:0000269|PubMed:32818467}. Lysosome {ECO:0000250|UniProtKB:O09046}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:25767141}. Note=Secreted at the immunological synapse. {ECO:0000269|PubMed:28891065}.
Mouse PG classificationNA
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