| Gene Information | |
|---|---|
| Gene Name | SHROOM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1616 |
| Protein Names | Protein Shroom2 (Apical-like protein) (Protein APXL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000146950 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13796 |
| Gene Card | SHROOM2 |
| Uniprot ID | Q13796 |
| Pfam | PF08688; PF08687; PF00595 |
| In ASD | no |
| Allosteric Prediction | no (-0.149195953) |
| Ortholog in Animals | Alpaca_ SHROOM2 ( ortholog_one2one ) Macaque_ SHROOM2 ( ortholog_one2one ) Mouse_ Shroom2 ( ortholog_one2one ) Pig_ SHROOM2 ( ortholog_one2one ) Rat_ Shroom2 ( ortholog_one2one ) |
| Ohnologs | SHROOM3 |
| Paralogs | SHROOM4, SHROOM1, SHROOM3 |
| Tissue | NA |
| Tissue Specificity | Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5F4Y (X-ray 3.29A ) 5F5P (X-ray 3.57A ) |
| DBSNP | rs16985780 rs1033602309 rs12012202 rs2073942 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associates with cortical F-actin. {ECO:0000250}. |
| Mouse PG classification | NA |
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