| Gene Information | |
|---|---|
| Gene Name | IL36G |
| Organism | Homo sapiens (Human) |
| Gene Length | 169 |
| Protein Names | Interleukin-36 gamma (IL-1-related protein 2) (IL-1RP2) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 9) (IL-1F9) (Interleukin-1 homolog 1) (IL-1H1) |
| Target Name | interleukin-36 gamma |
| Target Type | Clinical trial target |
| Gene Age | 244 ( ENSG00000136688 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NZH8 |
| Gene Card | IL36G |
| Uniprot ID | Q9NZH8 |
| Pfam | PF00340 |
| In ASD | no |
| Allosteric Prediction | no (-1.006299789) |
| Ortholog in Animals | Alpaca_ IL36G ( ortholog_one2one ) Macaque_ IL36G ( ortholog_one2one ) Mouse_ Il36g ( ortholog_one2one ) Rat_ Il36g ( ortholog_one2one ) Rabbit_ IL36G ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL36A, IL36B, IL37, IL1F10, IL1RN, IL36RN, IL1B |
| Tissue | tonsil, tongue, lower.leg.skin |
| Tissue Specificity | Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin. Expressed in monocyte-derived dendritic cells and M1 macrophages. {ECO:0000269|PubMed:20870894, ECO:0000269|PubMed:23095752}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4IZE (X-ray 2.00A ) 4P0J (X-ray 2.30A ) 4P0K (X-ray 1.70A ) 4P0L (X-ray 1.55A ) 6P9E (X-ray 2.00A ) |
| DBSNP | rs6707930 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:20870894}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}. |
| Mouse PG classification | NA |
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