| Gene Information | |
|---|---|
| Gene Name | IL36B |
| Organism | Homo sapiens (Human) |
| Gene Length | 164 |
| Protein Names | Interleukin-36 beta (FIL1 eta) (Interleukin-1 eta) (IL-1 eta) (Interleukin-1 family member 8) (IL-1F8) (Interleukin-1 homolog 2) (IL-1H2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000136696 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NZH7 |
| Gene Card | IL36B |
| Uniprot ID | Q9NZH7 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.836341225) |
| Ortholog in Animals | Dog_ IL36B ( ortholog_one2one ) Macaque_ IL36B ( ortholog_one2one ) Mouse_ Il36b ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL36G, IL36A, IL37, IL1F10, IL1RN, IL36RN, IL1B |
| Tissue | NA |
| Tissue Specificity | Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. {ECO:0000269|PubMed:20300079, ECO:0000269|PubMed:21242515}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34754959 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:16646978}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}. |
| Mouse PG classification | NA |
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